Use of a Novel EEG-Based Objective Test, the Cognalyzer(®), in Quantifying the Strength and Determining the Action Time of Cannabis Psychoactive Effects and Factors that May Influence Them Within an Observational Study Framework.
Use of a Novel EEG-Based Objective Test, the Cognalyzer(®), in Quantifying the Strength and Determining the Action Time of Cannabis Psychoactive Effects and Factors that May Influence Them Within an Observational Study Framework.
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DOI：
10.1007/s40120-021-00293-w
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发表时间：
2022-03
影响因子：
3.7
通讯作者：
Evans M
中科院分区：
文献类型：
--
作者：
Bosnyak D;McDonald AC;Gasperin Haaz I;Qi W;Crowley DC;Guthrie N;Evans M
目前检测最近使用δ-9-四氢大麻酚（THC）的方法无法客观量化其精神活性作用（PE）。Cognalyzer®是一种基于脑电图（EEG）的方法，可检测和量化THC诱导的PE强度，范围为0至100%。本研究评估了Cognalyzer® PE预测的幅度与大麻吸入后4小时报告的主观药物作用之间的关系。75名参与者参加了这项研究。在随意吸入大麻之前，完成EEG记录事件。吸入后立即进行药物效应问卷（DEQ），并进行另一次EEG记录。对于25名参与者，研究结束。对于50名参与者，以30分钟的间隔重复评估4小时。对EEG文件设盲，并使用两种版本的Cognalyzer®算法进行分析。使用广义线性模型和多元回归评估Cognalyzer® PE水平结果与DEQ之间的关系。从大麻前到3.5小时，PE显著增加。在所有吸入后时间点，感觉药物作用的平均报告均> 0（p ≤ 0.024）。此外，Cognalyzer® PE与自我报告的药物效应感知之间存在显著相关性（p ≤ 0.001）。亚组分析显示，Cognalyzer® PE水平受大麻使用史、药物作用的主观评级、口腔液体THC浓度和吸入的大麻产品的影响。研究结果表明，Cognalyzer®可用于客观地确定大麻产品对消费者产生的大麻精神活性作用的强度，以及它如何根据他们对大麻的体验而变化。Cognalyzer®可用于进行科学的消费者研究，以生成有关大麻产品精神活性体验的值得信赖的信息材料。对于临床研究，Cognalyzer®可用于研究大麻素或递送系统的药效学，如纳米药物。
Current methods to detect recent delta-9-tetrahydrocannabinol (THC) use cannot objectively quantify its psychoactive effects (PE). The Cognalyzer®, an electroencephalography (EEG)-based method, detects and quantifies the strength of THC-induced PE on a scale from 0 to 100%. This study assesses the relationship between the magnitude of Cognalyzer® PE predictions and reported subjective drug effects for 4-h post-cannabis inhalation. Seventy-five participants were enrolled in the study. Prior to ad libitum cannabis inhalation, an EEG recording episode was completed. Immediately after inhalation, the Drug Effects Questionnaire (DEQ) was administered and another EEG recording performed. For 25 participants, the study ended. For 50 participants, assessments were repeated at 30-min intervals for 4 h. EEG files were blinded and analyzed using two versions of the Cognalyzer® algorithm. The relationship between the Cognalyzer® PE level results and the DEQ was assessed using generalized linear models and multiple regression. There were significant PE increases from pre-cannabis for up to 3.5 h. Mean reports of feeling drug effects were > 0 at all post-inhalation time points (p ≤ 0.024). Furthermore, there were significant relationships between the Cognalyzer® PE and self-reported perception of drug effects (p ≤ 0.001). Subgroup analysis showed that Cognalyzer® PE levels were impacted by cannabis use history, subjective ratings of drug effects, oral fluid THC concentration and the cannabis product inhaled. The findings show that the Cognalyzer® can be used to objectively determine the strength of cannabis psychoactive effects that cannabis products create on consumers and how it changes depending on their experience with cannabis. The Cognalyzer® can be used to conduct scientific consumer research to generate trustworthy informational material about the psychoactive experience of cannabis products. For clinical research, the Cognalyzer® can be used to study the pharmacodynamics of cannabinoids or delivery systems, such as nano-emulsifications.
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影响因子：
3.8
作者：
McDonald AC;Gasperin Haaz I;Qi W;Crowley DC;Guthrie N;Evans M;Bosnyak D
通讯作者：
Bosnyak D
影响因子：
3
作者：
Spronk D;Dumont GJ;Verkes RJ;de Bruijn ER
通讯作者：
de Bruijn ER
影响因子：
3.6
作者：
Bocker, K. B. E.;Gerritsen, J.;Kenemans, J. L.
通讯作者：
Kenemans, J. L.
影响因子：
7.6
作者：
Cortes-Briones, Jose;Skosnik, Patrick D.;D'Souza, Deepak Cyril
通讯作者：
D'Souza, Deepak Cyril
影响因子：
4.2
作者：
Cooper, Ziva D.;Haney, Margaret
通讯作者：
Haney, Margaret