Changes with senescence in the fine structure of the granular convoluted tubule of the submandibular gland of the mouse.
Changes with senescence in the fine structure of the granular convoluted tubule of the submandibular gland of the mouse.
复制标题
小鼠颌下腺颗粒曲管精细结构随衰老的变化。
DOI：
10.1002/aja.1001840206
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Gresik,EW
中科院分区：
文献类型：
--
作者：
Gresik,EW
衰老雄性小鼠下颌下腺颗粒曲管（GCT）的细胞显示出指示功能衰退的结构变化。为了更清楚地定义这些年龄相关变化的性质，比较了12月龄和28月龄雄性GCT细胞的精细结构。在老年小鼠中，这些变化的程度存在细胞间差异，衰老雄性的一些细胞与年轻成年人的细胞没有什么不同。在受影响的细胞中，最显着的变化被认为是在分泌颗粒和溶酶体元素。分泌颗粒的大小变化很大，一些GCT细胞只有非常细的顶端颗粒。次级溶酶体和大的脂褐质颗粒常见于基底细胞质。在许多细胞中出现非常大的致密体（3 - 5 μm）。这些可能代表释放的分泌物质的细胞内池，因为它们偶尔与腔内容物连续可见。其外观介于非常大的致密体和脂褐质颗粒之间的结构是常见的，表明具有嗜软毛细胞活性。有一个明显的减少，在多聚核糖体的数量和高尔基体的范围。这些细微的结构变化与受影响的GCT细胞分泌产物的合成和翻译后加工中的高龄损伤一致。除了任何一只雄性动物的细胞间差异外，这些衰老变化的程度和范围也存在动物间差异。
Cells of the granular convoluted tubules (GCTs) of the submandibular glands of senescent male mice show structural changes indicative of functional decline. In order to define the nature of these age‐related changes more clearly, the fine structure of GCT cells of 12‐ and 28‐month‐old males was compared. In old mice, there was cell‐to‐cell variation in the extent of these changes, with some cells of senescent males appearing no different from those of young adults. In affected cells the most striking alterations were seen in secretion granules and lysosomal elements. Secretion granules varied greatly in size, with some GCT cells having only very fine apical granules. Secondary lysosomes and large lipofuscin granules were frequent in the basal cytoplasm. Very large dense bodies (3‐5 μm) occurred in many cells. These possibly represent intracellular pools of released secretory materials, as they were occasionally seen in continuity with the luminal contents. Structures whose appearance was intermediate between the very large dense bodies and lipofuscin granules were common, suggesting crinophagic activity. There was an apparent decrease in numbers of polysomes and in the extent of the Golgi apparatus. These fine structural changes are consistent with impairments with advanced age in synthesis and posttranslational processing of secretory products by affected GCT cells. In addition to cell‐to‐cell variation in any one male, there was also interanimal variation in the degree and extent of these senescent changes.
登录
查看更多内容
C57BL/6J 小鼠下颌下腺中 EGF 和蛋白酶的年龄相关变化。
影响因子：
1.8
作者：
Gresik,EW;Brennan,M;Azmitia,E
通讯作者：
Azmitia,E
影响因子：
--
作者：
HAND, AR
通讯作者：
HAND, AR
影响因子：
--
作者：
KIM, SK
通讯作者：
KIM, SK
衰老对大鼠颌下腺的影响：超微结构、细胞化学和生化研究
影响因子：
1.5
作者：
B. Bogart
通讯作者：
B. Bogart
影响因子：
3.9
作者：
KIM, SK;WEINHOLD, PA;HARTOG, VW
通讯作者：
HARTOG, VW