Beyond the Classic VTA: Extended Amygdala Projections to DA-Striatal Paths in the Primate.
Beyond the Classic VTA: Extended Amygdala Projections to DA-Striatal Paths in the Primate.
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DOI：
10.1038/npp.2017.38
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Ho B
中科院分区：
文献类型：
--
作者：
Fudge JL;Kelly EA;Pal R;Bedont JL;Park L;Ho B
中央延伸杏仁核（CEA）已被概念化为一个“宏系统”，调节各种应激诱导的行为。与此一致，CEA高度表达促肾上腺皮质激素释放因子（CRF），一种重要的应激反应调节因子。压力改变了与纹状体路径相关的目标导向反应，包括适应不良反应，如药物寻求，社交退缩和强迫行为。CEA输入中脑多巴胺（DA）系统的位置，通过中脑边缘DA-纹状体通路影响纹状体功能。然而，这种杏仁核-CEA-DA神经元通路的纹状体的结构在灵长类动物中的特征很差。在灵长类动物中，我们通过特定的DA亚群将神经元示踪剂注射到回路的各个臂中，以评估：（1）连接杏仁核、CEA和DA细胞的回路是否遵循CEA内在组织，或者涉及床核与中央核分裂的更直接的地形;（2）CEA-DA通路的CRF含量;（3）特别涉及CEA-DA-纹状体回路的纹状体亚区。我们发现，杏仁核-CEA-DA路径遵循宏观结构的细分，与大多数的输入/输出会聚在中央内侧核，豆状核下扩展杏仁核，和后外侧床核的终纹。CRF+输出的比例> 50%，并且主要靶向A10臂旁色素核（PBP）和A8（红核后野，RRF）神经元亚群，具有到背侧A9神经元的额外输入。CRF富集的CEA-DA预测被定位为影响到“边缘相关”纹状体的输出，这与缺乏CEA输入的DA细胞靶向的纹状体区域不同。我们的结论是，CEA的概念是支持连接的理由，CEA终止的PBP和RRF神经元群体可以影响纹状体回路参与联想学习。
The central extended amygdala (CEA) has been conceptualized as a ‘macrosystem’ that regulates various stress-induced behaviors. Consistent with this, the CEA highly expresses corticotropin-releasing factor (CRF), an important modulator of stress responses. Stress alters goal-directed responses associated with striatal paths, including maladaptive responses such as drug seeking, social withdrawal, and compulsive behavior. CEA inputs to the midbrain dopamine (DA) system are positioned to influence striatal functions through mesolimbic DA-striatal pathways. However, the structure of this amygdala-CEA-DA neuron path to the striatum has been poorly characterized in primates. In primates, we combined neuronal tracer injections into various arms of the circuit through specific DA subpopulations to assess: (1) whether the circuit connecting amygdala, CEA, and DA cells follows CEA intrinsic organization, or a more direct topography involving bed nucleus vs central nucleus divisions; (2) CRF content of the CEA-DA path; and (3) striatal subregions specifically involved in CEA-DA-striatal loops. We found that the amygdala-CEA-DA path follows macrostructural subdivisions, with the majority of input/outputs converging in the medial central nucleus, the sublenticular extended amygdala, and the posterior lateral bed nucleus of the stria terminalis. The proportion of CRF+ outputs is >50%, and mainly targets the A10 parabrachial pigmented nucleus (PBP) and A8 (retrorubal field, RRF) neuronal subpopulations, with additional inputs to the dorsal A9 neurons. CRF-enriched CEA-DA projections are positioned to influence outputs to the ‘limbic-associative’ striatum, which is distinct from striatal regions targeted by DA cells lacking CEA input. We conclude that the concept of the CEA is supported on connectional grounds, and that CEA termination over the PBP and RRF neuronal populations can influence striatal circuits involved in associative learning.
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影响因子：
3.3
作者：
Cho, Y. T.;Fudge, J. L.
通讯作者：
Fudge, J. L.
DOI：
10.1007/bf00325634
发表时间：
1971-01-01
期刊：
ZEITSCHRIFT FUR ZELLFORSCHUNG UND MIKROSKOPISCHE ANATOMIE
影响因子：
--
作者：
GENESERJENSEN, FA;BLACKSTAD, TW
通讯作者：
BLACKSTAD, TW
影响因子：
16.2
作者：
Bromberg-Martin, Ethan S.;Matsumoto, Masayuki;Hikosaka, Okihide
通讯作者：
Hikosaka, Okihide
影响因子：
2.5
作者：
HABER, SN;RYOO, H;LU, W
通讯作者：
LU, W
影响因子：
2.5
作者：
CASSELL, MD;GRAY, TS
通讯作者：
GRAY, TS