Altered spontaneous brain activity in primary open angle glaucoma: a resting-state functional magnetic resonance imaging study.
Altered spontaneous brain activity in primary open angle glaucoma: a resting-state functional magnetic resonance imaging study.
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原发性开角型青光眼自发大脑活动的改变：静息态功能磁共振成像研究。
DOI：
10.1371/journal.pone.0089493
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Song Y;Mu K;Wang J;Lin F;Chen Z;Yan X;Hao Y;Zhu W;Zhang H
既往研究表明原发性开角型青光眼（POAG）与脑结构异常有关；然而，人们对自发活动局部同步的变化知之甚少。本研究的主要目的是使用基于静息状态功能磁共振成像（rs-fMRI）的区域均匀性（ReHo）分析来研究POAG患者的自发脑活动。39名POAG患者和41名年龄和性别匹配的健康对照者最终被纳入研究。采用ReHo值评估脑自发活动，并对全脑体素进行ReHo分析，以检测各组间脑自发活动的区域差异。与对照组相比，POAG患者右侧前扣带皮层背侧、双侧额叶内侧回和右侧小脑前叶的ReHo升高，双侧胼胝体、双侧楔前叶、双侧中央前/后回、左侧顶叶下小叶和左侧小脑后叶的ReHo降低。采用多元线性回归分析临床指标与区域间ReHo的关系，POAG组差异有统计学意义。年龄与额上回（r = - 0.323, p = 0.045）、左脑钙（r = - 0.357, p = 0.026）、下顶叶（r = - 0.362, p = 0.024）的ReHo值呈负相关。左楔前叶的ReHo值与累积平均缺损呈负相关（r = - 0.400, p = 0.012）。POAG与大脑某些区域的异常自发活动有关，这种区域活动的变化可能与临床参数有关。自发性脑活动可能在POAG的发生和发展中起作用。
Previous studies demonstrated that primary open angle glaucoma (POAG) is associated with abnormal brain structure; however, little is known about the changes in the local synchronization of spontaneous activity. The main objective of this study was to investigate spontaneous brain activity in patients with POAG using regional homogeneity (ReHo) analysis based on resting state functional magnetic resonance imaging (rs-fMRI). Thirty-nine POAG patients and forty-one age- and gender- matched healthy controls were finally included in the study. ReHo values were used to evaluate spontaneous brain activity and whole brain voxel-wise analysis of ReHo was carried out to detect differences by region in spontaneous brain activity between groups. Compared to controls, POAG patients showed increased ReHo in the right dorsal anterior cingulated cortex, the bilateral medial frontal gyrus and the right cerebellar anterior lobe, and decreased ReHo in the bilateral calcarine, bilateral precuneus gryus, bilateral pre/postcentral gyrus, left inferior parietal lobule and left cerebellum posterior lobe. A multiple linear regression analysis was performed to explore the relationships between clinical measures and ReHo by region showed significant group differences in the POAG group. Negative correlations were found between age and the ReHo values of the superior frontal gyrus (r = −0.323, p = 0.045), left calcarine (r = −0.357, p = 0.026) and inferior parietal lobule (r = −0.362, p = 0.024). A negative correlation was found between the ReHo values of the left precuneus and the cumulative mean defect (r = −0.400, p = 0.012). POAG was associated with abnormal brain spontaneous activity in some brain regions and such changed regional activity may be associated with clinical parameters. Spontaneous brain activity may play a role in POAG initiation and progression.
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