Complement C1q formation of immune complexes with milk caseins and wheat glutens in schizophrenia.
Complement C1q formation of immune complexes with milk caseins and wheat glutens in schizophrenia.
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DOI：
10.1016/j.nbd.2012.07.005
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发表时间：
2012-12
影响因子：
6.1
通讯作者：
Yolken RH
中科院分区：
文献类型：
--
作者：
Severance EG;Gressitt KL;Halling M;Stallings CR;Origoni AE;Vaughan C;Khushalani S;Alaedini A;Dupont D;Dickerson FB;Yolken RH
包括补体途径激活在内的免疫系统因素越来越多地与精神分裂症的病因学和病理生理学相关。补体蛋白 C1q 结合并帮助清除由与抗原偶联的免疫球蛋白组成的免疫复合物。精神分裂症中 C1q 激活的抗原刺激尚不清楚。据报道，精神分裂症患者对食物过敏，其特征是对牛乳酪蛋白和小麦麸质的 IgG 抗体升高。在这里，我们检查了这些食品可能在近期发病的精神分裂症患者 (n=38)、非近期发病的精神分裂症患者 (n=61) 和非精神病对照者 (n=63) 的个体中包含补体 C1q 免疫复合物的抗原成分的程度。与对照组相比（校正年龄、性别、种族和吸烟状况的逻辑回归模型），C1q 血清阳性与两个精神分裂症组（近期发病，比值比 (OR)=8.02，p≤0.008；非近期发病，OR=3.15，p≤0.03）显着相关。与对照组相比，非近期发病组的酪蛋白和/或麸质 IgG 与 C1q 的结合显着升高（OR=4.36，p≤0.01）。在非新近发病的精神分裂症中，大量的 C1q-酪蛋白/麸质相关免疫复合物以及 C1q 与胃肠道炎症标志物的相关性表明，系统循环中食物抗原的比率升高，这可能是通过与疾病相关的肠道通透性改变而实现的。在疾病发作早期的个体中，C1q 激活可能反映了与非酪蛋白或非麸质相关抗原的免疫复合物的形成、C1q 自身抗体的存在和/或免疫复合物成分的解离状态。总之，补体激活可能是在精神分裂症病程早期诊断的有用生物标志物。未来的前瞻性研究应评估无酪蛋白和无麸质饮食对精神分裂症 C1q 激活的影响。
Immune system factors including complement pathway activation are increasingly linked to the etiology and pathophysiology of schizophrenia. Complement protein, C1q, binds to and helps to clear immune complexes composed of immunoglobulins coupled to antigens. The antigenic stimuli for C1q activation in schizophrenia are not known. Food sensitivities characterized by elevated IgG antibodies to bovine milk caseins and wheat glutens have been reported in individuals with schizophrenia. Here, we examined the extent to which these food products might comprise the antigen component of complement C1q immune complexes in individuals with recent onset schizophrenia (n=38), non-recent onset schizophrenia (n=61) and non-psychiatric controls (n=63). C1q seropositivity was significantly associated with both schizophrenia groups (recent onset, odds ratio (OR)=8.02, p≤0.008; non-recent onset, OR=3.15, p≤0.03) compared to controls (logistic regression models corrected for age, sex, race and smoking status). Casein- and/or gluten-IgG binding to C1q was significantly elevated in the non-recent onset group compared to controls (OR=4.36, p≤0.01). Significant amounts of C1q-casein/gluten-related immune complexes and C1q correlations with a marker for gastrointestinal inflammation in non-recent onset schizophrenia suggests a heightened rate of food antigens in the systemic circulation, perhaps via a disease-associated altered intestinal permeability. In individuals who are in the early stages of disease onset, C1q activation may reflect the formation of immune complexes with non-casein- or non-gluten-related antigens, the presence of C1q autoantibodies, and/or a dissociated state of immune complex components. In conclusion, complement activation may be a useful biomarker to diagnose schizophrenia early during the course of the disease. Future prospective studies should evaluate the impacts of casein- and gluten-free diets on C1q activation in schizophrenia.
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影响因子：
--
作者：
Arakelyan, Arsen;Zakharyan, Roksana;Boyajyan, Anna
通讯作者：
Boyajyan, Anna
影响因子：
15.9
作者：
CUNNINGHAMRUNDLES, C;BRANDEIS, WE;DAY, NK
通讯作者：
DAY, NK
DOI：
10.1073/pnas.75.7.3387
发表时间：
1978-01-01
影响因子：
11.1
作者：
CUNNINGHAMRUNDLES, C;BRANDEIS, WE;DAY, NK
通讯作者：
DAY, NK
影响因子：
17.7
作者：
Karlsson, Hakan;Blomstrom, Asa;Dalman, Christina
通讯作者：
Dalman, Christina
影响因子：
4.5
作者：
Niebuhr, David W.;Li, Yuanzhang;Yolken, Robert
通讯作者：
Yolken, Robert