Muscarinic receptors regulate auditory and prefrontal cortical communication during auditory processing.
Muscarinic receptors regulate auditory and prefrontal cortical communication during auditory processing.
复制标题
毒蕈碱受体调节听觉处理过程中听觉和前额叶皮质交流。
DOI：
10.1016/j.neuropharm.2018.10.027
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发表时间：
2019-01
影响因子：
4.7
通讯作者：
Han X
中科院分区：
文献类型：
--
作者：
James NM;Gritton HJ;Kopell N;Sen K;Han X
我们对乙酰胆碱如何调节前额叶皮层（PFC）网络的理解大多来自于行为实验，这些实验研究了高度注意状态下的皮层动力学。然而，关于PFC在被动感觉处理过程中是如何被招募的，以及乙酰胆碱如何调节任务执行之外的皮层区域之间的连通性，人们知之甚少。为了研究PFC和胆碱能神经调节在被动听觉处理中的作用，我们在清醒的头部固定小鼠的听觉皮层（AC）和PFC中进行了同时记录，在AC中存在或不存在局部胆碱能拮抗剂的情况下，提供白色噪声听觉刺激。我们发现，一个子集的PFC神经元强烈驱动的听觉刺激，即使刺激没有联想意义，这表明PFC监视器的被动条件下的刺激。我们还发现AC中的胆碱能信号通过AC中的毒蕈碱相互作用调节皮层内感觉反应，从而塑造PFC中听觉驱动反应的强度。两者合计，这些研究结果提供了新的证据表明，胆碱能机制有一个连续的作用，在皮层门控通过毒蕈碱受体在被动处理和扩展的传统观点的前额叶皮层功能和胆碱能调制的贡献，在皮层通信。
Much of our understanding about how acetylcholine modulates prefrontal cortical (PFC) networks comes from behavioral experiments that examine cortical dynamics during highly attentive states. However, much less is known about how PFC is recruited during passive sensory processing and how acetylcholine may regulate connectivity between cortical areas outside of task performance. To investigate the involvement of PFC and cholinergic neuromodulation in passive auditory processing, we performed simultaneous recordings in the auditory cortex (AC) and PFC in awake head fixed mice presented with a white noise auditory stimulus in the presence or absence of local cholinergic antagonists in AC. We found that a subset of PFC neurons were strongly driven by auditory stimuli even when the stimulus had no associative meaning, suggesting PFC monitors stimuli under passive conditions. We also found that cholinergic signaling in AC shapes the strength of auditory driven responses in PFC, by modulating the intra-cortical sensory response through muscarinic interactions in AC. Taken together, these findings provide novel evidence that cholinergic mechanisms have a continuous role in cortical gating through muscarinic receptors during passive processing and expand traditional views of prefrontal cortical function and the contributions of cholinergic modulation in cortical communication.
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影响因子：
3.7
作者：
Chang CH;Berke JD;Maren S
通讯作者：
Maren S
影响因子：
2.3
作者：
ASHE, JH;MCKENNA, TM;WEINBERGER, NM
通讯作者：
WEINBERGER, NM
DOI：
10.1073/pnas.1402436111
发表时间：
2014-06-03
影响因子：
11.1
作者：
Deckmann, Klaus;Filipski, Katharina;Kummer, Wolfgang
通讯作者：
Kummer, Wolfgang
影响因子：
25
作者：
Fritz, Jonathan B.;David, Stephen V.;Radtke-Schuller, Susanne;Yin, Pingbo;Shamma, Shihab A.
通讯作者：
Shamma, Shihab A.
影响因子：
16.2
作者：
Euston DR;Gruber AJ;McNaughton BL
通讯作者：
McNaughton BL