Health-related quality of life in morphoea.
Health-related quality of life in morphoea.
复制标题
形态上与健康相关的生活质量。
DOI：
10.1111/bjd.13572
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Jacobe H
中科院分区：
文献类型：
--
作者：
Klimas NK;Shedd AD;Bernstein IH;Jacobe H
关于硬斑病患者的健康相关生活质量（HRQOL）知之甚少，以前的研究得出了相互矛盾的结果。确定硬斑病对HRQOL的影响以及成人HRQOL的临床和人口统计学相关性。成人和儿童睡眠症（MAC）队列的横断面调查（n=73）。Morphea损害成人的HRQOL。患者的情绪健康和担心疾病会发展到他们的内部器官。黑色素瘤患者的皮肤特异性HRQOL比非黑色素瘤皮肤癌、白癜风和脱发患者差（P <0.0001）。除身体疼痛外，研究受试者的所有子量表（所有P ≤.004）的总体HRQOL评分均显著低于美国普通人群。合并症（r = 0.35 - 0.51，P ≤ 0.0029 - 0.0001）、瘙痒症状（r = 0.38 - 0.64，P ≤ 0.001 - 0.0001）和疼痛（r = 0.46 - 0.74，P <0.0001）与皮肤特异性和整体HRQOL多个领域的损害相关。基于医生的疾病严重程度指标与患者报告的HRQOL相关。硬斑病患者对HRQOL有负面影响，特别是如果存在症状（瘙痒和疼痛）或对内部表现的担忧。医生在评估和治疗患者时应该意识到这一点。
Little is known about the health-related quality of life (HRQOL) of patients with morphea, and previous studies have yielded conflicting results. To determine the impact of morphea on HRQOL and clinical and demographic correlates of HRQOL in adults. Cross sectional survey (n=73) of Morphea in Adults and Children (MAC) cohort. Morphea impairs HRQOL in adults. Patients were most impaired by emotional well-being and concerns that the disease will progress to their internal organs. Patients with morphea had worse skin-specific HRQOL than those with non-melanoma skin cancer, vitiligo, and alopecia (lowest P <.0001). Study subjects had significantly worse global HRQOL scores than the general U.S. population for all subscales (all P ≤.004) with the exception of bodily pain. Comorbidity (r =.35-.51, P ≤ .0029 -.0001) and symptoms of pruritus (r =.38 -.64, P ≤.001-.0001) and pain (r =.46-.74, P <.0001) were associated with impairment in multiple domains of skin-specific and global HRQOL. Physician-based measures of disease severity correlated with patient-reported HRQOL. Patients with morphea have negative impact on HRQOL particularly if symptoms (pruritus and pain) or concerns regarding internal manifestations are present. Providers should be aware of this when evaluating and treating patients.
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影响因子：
6.5
作者：
Grozdev, Ivan;Kast, Douglas;Gao, Lauren;Carlson, Diana;Pujari, Prasad;Schmotzer, Brian;Babineau, Denise;Kern, Elizabeth;McCormick, Thomas;Cooper, Kevin D.;Korman, Neil J.
通讯作者：
Korman, Neil J.
影响因子：
4.3
作者：
Mendez-Sanchez, Nahum;Chavez-Tapia, Norberto C.;Uribe, Misael
通讯作者：
Uribe, Misael
影响因子：
10.3
作者：
Dominguez, P. L.;Assarpour, A.;Qureshi, A. A.
通讯作者：
Qureshi, A. A.
影响因子：
10.3
作者：
Gisondi, P.;Tessari, G.;Girolomoni, G.
通讯作者：
Girolomoni, G.
影响因子：
3.4
作者：
Naldi, Luigi;Chatenoud, Liliane;Parazzini, Fabio
通讯作者：
Parazzini, Fabio