Human papillomavirus in semen and the risk for male infertility: a systematic review and meta-analysis.
Human papillomavirus in semen and the risk for male infertility: a systematic review and meta-analysis.
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精液中的人乳头瘤病毒与男性不育的风险：系统评价和荟萃分析
DOI：
10.1186/s12879-017-2812-z
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发表时间：
2017-11-09
影响因子：
3.7
通讯作者：
Dai M
中科院分区：
文献类型：
--
作者：
Lyu Z;Feng X;Li N;Zhao W;Wei L;Chen Y;Yang W;Ma H;Yao B;Zhang K;Hu Z;Shen H;Hang D;Dai M
人乳头瘤病毒（HPV）是最常见的性传播病毒之一。尽管越来越多的证据表明精液中HPV的流行，但精液中HPV类型的全球分布和男性不育的风险仍然没有定论。检索了4个电子数据库，以查找1990年1月至2016年12月期间进行的报告精液中HPV DNA患病率的英语研究。根据PRISMA指南，分别在一般人群和生育诊所就诊者中估计HPV患病率，并使用Cochran's Q和I2统计量进行异质性检验。通过病例对照研究的荟萃分析评估HPV阳性与男性不育之间的关联。共纳入了31项合格研究，包括5194例男性。精液中HPV DNA的总患病率在普通人群（n = 2122）中为11.4%（95%CI = 7.8-15.0%），在生育诊所就诊者（n = 3072）中为20.4%（95%CI = 16.2-24.6%）。高危型患病率分别为10.0%（95%CI = 5.9-14.0%）和15.5%（95%CI = 11.4-19.7%）。HPV 16是最常见的型别，在一般人群中的患病率为4.8%（95%CI = 1.7-7.8%），在生育门诊就诊者中的患病率为6.0%（95%CI = 3.8-8.2%）。精液中HPV阳性者不育的危险性显著增加（OR = 2.93，95% CI = 2.03-4.24）。精液HPV感染在世界范围内很常见，这可能会导致男性不育的风险。本文的在线版本（10.1186/s12879-017-2812-z）包含补充材料，可供授权用户使用。
Human papillomavirus (HPV) is one of the most prevalent sexually transmitted viruses. Despite the increasing evidence of HPV prevalence in semen, the worldwide distribution of HPV types in semen and risk for male infertility remain inconclusive. Four electronic databases were searched for English language studies conducted between January 1990 and December 2016 that reported HPV DNA prevalence in semen. Based on the PRISMA guidelines, HPV prevalence was estimated among general population and fertility clinic attendees, respectively, and heterogeneity testing was performed using Cochran’s Q and I 2 statistics. The association between HPV positivity and male infertility was evaluated by a meta-analysis of case-control studies. A total of 31 eligible studies comprising 5194 males were included. The overall prevalence of HPV DNA in semen was 11.4% (95% CI = 7.8-15.0%) in general population (n = 2122) and 20.4% (95% CI = 16.2-24.6%) in fertility clinic attendees (n = 3072). High-risk type prevalence was 10.0% (95% CI = 5.9-14.0%) and 15.5% (95% CI = 11.4-19.7%), respectively. HPV16 was the most common type, with a prevalence of 4.8% (95% CI = 1.7-7.8%) in general population and 6.0% (95% CI = 3.8-8.2%) in fertility clinic attendees. A significantly increased risk of infertility was found for males with HPV positivity in semen (OR = 2.93, 95% CI = 2.03-4.24). Seminal HPV infection is common worldwide, which may contribute to the risk of male infertility. The online version of this article (10.1186/s12879-017-2812-z) contains supplementary material, which is available to authorized users.
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影响因子：
5.3
作者：
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