Alterations in sucrose sham-feeding intake as a function of diet-exposure in rats maintained on calorically dense diets.
Alterations in sucrose sham-feeding intake as a function of diet-exposure in rats maintained on calorically dense diets.
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DOI：
10.1016/j.appet.2015.05.014
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发表时间：
2015-09
期刊：
影响因子：
5.4
通讯作者：
Moran, Timothy H.
中科院分区：
文献类型：
--
作者：
Treesukosol, Yada;Liang, Nu-Chu;Moran, Timothy H.
我们以前曾报道，大鼠增加膳食规模后，最初介绍了热量密集的饮食。这种增加可能是由于口感觉刺激增加和/或对摄食后抑制信号的敏感性降低。在喂食过程中，两种类型的信号同时起作用，因此在这里，我们比较了大鼠的反应，提出了高能量饮食（HE）或45%的高脂肪饮食（HF）与那些在假喂食过程中，摄食后反馈最小化的饲料喂养控制（CHOW）。在饮食操作前（基线）、引入适口饮食后约5天（动态阶段）和约6周（静态阶段）以及动物转换回标准食物后（恢复阶段），对蔗糖进行假喂食测量。一些但不是所有的假设，基于我们以前的研究结果证实了这里的结果。与我们的假设，增强orosensory刺激在动态阶段与静态阶段相比，将概括为其他可口的刺激摄入量增加，HE大鼠表现出较高的蔗糖摄入量在动态阶段与静态阶段相比。与我们的假设相反，HE和HF大鼠与CHOW大鼠相比没有增加对蔗糖的反应。事实上，与CHOW对照组相比，HE大鼠显示出降低的反应。因此，口腔感觉刺激的变化并不一定普遍增加其他可口的刺激摄入量。
We previously reported that rats increase meal size upon initial presentation of a calorically dense diet. The increase may be attributed to increased orosensory stimulation and/or reduced sensitivity to post-ingestive inhibitory signals. During feeding both types of signals are simultaneously in play thus here, we compare responses in rats presented a high-energy diet (HE) or 45% high-fat diet (HF) with those of chow-fed controls (CHOW) in a sham-feeding procedure in which post-ingestive feedback is minimized. Measures of sham-feeding to sucrose were taken before diet manipulation (baseline), ~5 days (dynamic phase) and ~ 6 weeks (static phase) following introduction of the palatable diet, as well as after animals were switched back to standard chow (recovery phase). Some but not all the hypotheses based on our previous findings were confirmed by the outcomes here. Consistent with our hypothesis that enhanced orosensory stimulation during the dynamic phase compared with the static phase would generalize to increased intake of other palatable stimuli, HE rats showed higher sucrose intake during the dynamic phase compared with the static phase. Contrary to what we hypothesized, HE and HF rats did not increase responses to sucrose compared to CHOW rats. In fact, HE rats showed decreased responses compared to CHOW controls. Thus changes in orosensory stimulation do not necessarily generalize to increased intake of other palatable stimuli.
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