Acute exacerbation of idiopathic pulmonary fibrosis associated with air pollution exposure.
Acute exacerbation of idiopathic pulmonary fibrosis associated with air pollution exposure.
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DOI：
10.1183/09031936.00122213
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Collard HR
中科院分区：
文献类型：
--
作者：
Johannson KA;Vittinghoff E;Lee K;Balmes JR;Ji W;Kaplan GG;Kim DS;Collard HR
特发性肺纤维化的急性加重与高死亡率相关，原因不明。空气污染对间质性肺病加重的影响尚不清楚。本研究旨在明确空气污染暴露与特发性肺纤维化急性加重之间的关系。特发性肺纤维化患者和相应的空气污染数据来自纵向队列。根据地理编码的住址，将臭氧、二氧化氮、颗粒物、二氧化硫和一氧化碳的空气污染暴露分配给每个患者。COX比例风险模型被用来估计空气污染暴露与急性加重之间的关联。臭氧(危害比)1.57，95%可信区间1.09-2.24；危害比1.42，95%可信区间1.11-1.82；二氧化氮水平1.41，95%可信区间1.04-1.91；二氧化氮1.27，95%可信区间1.01-1.59；HR为1.20，95%CI为1.10~1.31)。在过去的6周内，臭氧和二氧化氮暴露的增加与特发性肺纤维化急性加重的风险增加有关，这表明空气污染可能有助于这一具有临床意义的事件的发生。
Acute exacerbations of idiopathic pulmonary fibrosis are associated with high mortality and are of unknown cause. The effect of air pollution on exacerbations of interstitial lung disease is unknown. This study aims to define the association of air pollution exposure with acute exacerbation of idiopathic pulmonary fibrosis. Patients with idiopathic pulmonary fibrosis and corresponding air pollution data were identified from a longitudinal cohort. Air pollution exposures were assigned to each patient for ozone, nitrogen dioxide, particulate matter, sulfur dioxide and carbon monoxide based on geo-coded residential addresses. Cox proportional hazards models were used to estimate the association of air pollution exposures and acute exacerbations. Acute exacerbation was significantly associated with antecedent 6-week increases in mean level, maximum level and number of exceedances above accepted standards of ozone (hazard ratio (HR) 1.57, 95% CI 1.09–2.24; HR 1.42, 95% CI 1.11–1.82; and HR 1.51, 95% CI 1.17–1.94, respectively) and nitrogen dioxide (HR 1.41, 95% CI 1.04–1.91; HR 1.27, 95% CI 1.01–1.59; and HR 1.20, 95% CI 1.10–1.31, respectively). Increased ozone and nitrogen dioxide exposure over the preceding 6 weeks was associated with an increased risk of acute exacerbation of idiopathic pulmonary fibrosis, suggesting that air pollution may contribute to the development of this clinically meaningful event.
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DOI：
10.1056/nejmsa0805646
发表时间：
2009-01-22
期刊：
The New England journal of medicine
影响因子：
--
作者：
Pope CA 3rd;Ezzati M;Dockery DW
通讯作者：
Dockery DW
影响因子：
5.8
作者：
Schikowski T;Sugiri D;Ranft U;Gehring U;Heinrich J;Wichmann HE;Krämer U
通讯作者：
Krämer U
影响因子：
24.3
作者：
Beeh, KM;Beier, J;Buhl, R
通讯作者：
Buhl, R
DOI：
10.1164/rccm.2111021
发表时间：
2002-07-01
影响因子：
24.7
作者：
Gauderman, WJ;Gilliland, GF;Peters, JM
通讯作者：
Peters, JM
影响因子：
6.3
作者：
Meng, Ying-Ying;Rull, Rudolph P.;Ritz, Beate
通讯作者：
Ritz, Beate