Circadian, Reward, and Emotion Systems in Teens prospective longitudinal study: protocol overview of an integrative reward-circadian rhythm model of first onset of bipolar spectrum disorder in adolescence.
Circadian, Reward, and Emotion Systems in Teens prospective longitudinal study: protocol overview of an integrative reward-circadian rhythm model of first onset of bipolar spectrum disorder in adolescence.
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DOI：
10.1186/s12888-023-05094-z
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发表时间：
2023-08-17
期刊：
影响因子：
4.4
通讯作者：
Nusslock, Robin
中科院分区：
文献类型：
--
作者：
Alloy, Lauren B.;Walsh, Rachel F. L.;Smith, Logan T.;Maddox, Mackenzie A.;Olino, Thomas M.;Zee, Phyllis C.;Nusslock, Robin
关键词：
双相谱系障碍（BSD）与皮质-纹状体回路中对奖励的高度敏感性和与奖励相关的脑功能升高有关。另一篇文献记录了BSD中的社会和昼夜节律破坏。最近，已经提出了BSD的综合奖励昼夜节律模型。这些模型借鉴的工作表明，这两个系统相互影响，相互作用，影响情绪功能。当失调时，奖赏和昼夜节律系统信号传导可以联合收割机以形成正反馈回路，由此一个系统中的失调加剧另一个系统中的失调。CREST项目（青少年的昼夜节律，奖励和情绪系统）提供了奖励昼夜节律失调的第一个系统性测试，作为BSD首次发作和青春期双相症状增加的协同和动态脆弱性。这项由NIMH资助的R 01研究是一项为期3年的前瞻性纵向调查，涉及来自美国费城地区的约320名社区青少年。符合条件的参与者必须是13-16岁，英语流利，并且之前没有BSD或轻躁狂发作。他们被选择沿着自我报告的奖励反应的整个维度，在维度的高尾部进行过采样，以增加BSD发作的可能性。在时间1-6，每6个月，参与者将完成对奖励相关和社会节律破坏生活事件的评估，以及对双相症状和发作的自我报告和诊断评估。每年，在时间1，3和5，参与者还将完成昼夜节律时间型（早晨-晚上）和社会节律规律性的自我报告测量，唾液昏暗光褪黑激素发作（DLMO）程序，以评估昼夜节律阶段，自我报告，行为和神经（fMRI）评估货币和社会奖励反应，以及7天的生态瞬时评估（EMA）期。在每个EMA期间，受试者将完成睡眠/觉醒和活动（活动记录）的连续测量，每日睡眠日记和三个日内（上午，下午，晚上）生活事件的测量，编码为奖励相关性和社会节奏中断，金钱和社会奖励反应，积极和消极影响，以及低/躁狂和抑郁症状。fMRI扫描将在前一天进行，DLMO程序将在7天EMA期的第一天晚上进行。这项研究是对涉及奖励和昼夜信号的多器官系统研究的创新整合，以了解青春期首次发作的BSD。它有可能促进新的药理学，神经和行为干预，以治疗和理想地预防双相情感障碍。在线版本包含补充材料，可通过10.1186/s12888-023-05094-z获得。
Bipolar spectrum disorders (BSDs) are associated with a heightened sensitivity to rewards and elevated reward-related brain function in cortico-striatal circuitry. A separate literature documents social and circadian rhythm disruption in BSDs. Recently, integrated reward-circadian models of BSDs have been proposed. These models draw on work indicating that the two systems influence each other and interact to affect mood functioning. When dysregulated, reward and circadian system signaling may combine to form a positive feedback loop, whereby dysregulation in one system exacerbates dysregulation in the other. Project CREST (Circadian, Reward, and Emotion Systems in Teens) provides a first systematic test of reward-circadian dysregulation as a synergistic and dynamic vulnerability for first onset of BSD and increases in bipolar symptoms during adolescence. This NIMH-funded R01 study is a 3-year prospective, longitudinal investigation of approximately 320 community adolescents from the broader Philadelphia area, United States of America. Eligible participants must be 13–16 years old, fluent in English, and without a prior BSD or hypomanic episode. They are being selected along the entire dimension of self-reported reward responsiveness, with oversampling at the high tail of the dimension in order to increase the likelihood of BSD onsets. At Times 1–6, every 6 months, participants will complete assessments of reward-relevant and social rhythm disruption life events and self-report and diagnostic assessments of bipolar symptoms and episodes. Yearly, at Times 1, 3, and 5, participants also will complete self-report measures of circadian chronotype (morningness-eveningness) and social rhythm regularity, a salivary dim light melatonin onset (DLMO) procedure to assess circadian phase, self-report, behavioral, and neural (fMRI) assessments of monetary and social reward responsiveness, and a 7-day ecological momentary assessment (EMA) period. During each EMA period, participants will complete continuous measures of sleep/wake and activity (actigraphy), a daily sleep diary, and three within-day (morning, afternoon, evening) measures of life events coded for reward-relevance and social rhythm disruption, monetary and social reward responsiveness, positive and negative affect, and hypo/manic and depressive symptoms. The fMRI scan will occur on the day before and the DLMO procedure will occur on the first evening of the 7-day EMA period. This study is an innovative integration of research on multi-organ systems involved in reward and circadian signaling in understanding first onset of BSD in adolescence. It has the potential to facilitate novel pharmacological, neural, and behavioral interventions to treat, and ideally prevent, bipolar conditions. The online version contains supplementary material available at 10.1186/s12888-023-05094-z.
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影响因子：
4.6
作者：
Alloy LB;Urošević S;Abramson LY;Jager-Hyman S;Nusslock R;Whitehouse WG;Hogan M
通讯作者：
Hogan M
影响因子：
4.6
作者：
Alloy LB;Boland EM;Ng TH;Whitehouse WG;Abramson LY
通讯作者：
Abramson LY
DOI：
10.1080/15374416.2019.1567347
发表时间：
2019-01-01
影响因子：
4.2
作者：
Alloy, Lauren B.;Nusslock, Robin
通讯作者：
Nusslock, Robin
影响因子：
4.6
作者：
Bart CP;Nusslock R;Ng TH;Titone MK;Carroll AL;Damme KSF;Young CB;Armstrong CC;Chein J;Alloy LB
通讯作者：
Alloy LB
影响因子：
5.4
作者：
Alloy, Lauren B.;Abramson, Lyn Y.;Hogan, Michael E.
通讯作者：
Hogan, Michael E.