Interleukin-1 beta single-nucleotide polymorphism's C allele is associated with elevated risk of gastric cancer in Helicobacter pylori-infected Peruvians.
Interleukin-1 beta single-nucleotide polymorphism's C allele is associated with elevated risk of gastric cancer in Helicobacter pylori-infected Peruvians.
复制标题
DOI：
10.4269/ajtmh.2009.08-0494
复制
发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Gilman RH
中科院分区：
文献类型：
--
作者：
Gehmert S;Velapatiño B;Herrera P;Balqui J;Santivañez L;Cok J;Vargas G;Combe J;Passaro DJ;Wen S;Meyer F;Berg DE;Gilman RH
在东亚和欧洲人群中，白细胞介素-1B（IL-1B）基因的特定等位基因与萎缩性胃炎和胃癌的风险增加相关。秘鲁没有这样的数据，这是一个发展中国家，其人群的基因型与其他研究人群不同，幽门螺杆菌感染和胃癌的患病率很高。我们进行了一项病例对照研究，比较了334例萎缩性胃炎或胃癌住院患者和158例非萎缩性胃炎患者（对照组）。条件Logistic回归分析显示，萎缩性胃炎（比值比，5.60）和胃癌（比值比，2.36）的风险增加与IL-1B-511 C等位基因相关。我们的研究是第一个将该等位基因确定为这些疾病的风险。鉴于H. pylori和治疗后复发率，IL-1B-511单核苷酸多态性分析可能会识别出哪些人将受益于强大的H。秘鲁根除幽门螺杆菌的工作。
Particular alleles of the interleukin-1B (IL-1B) gene have been correlated with increased risk of atrophic gastritis and gastric cancer in the populations of East Asia and Europe. No such data exist from Peru, a developing country with a population genotypically different from others studied and with a high prevalence of Helicobacter pylori infection and gastric cancer. We conducted a case-control study comparing 334 hospitalized patients with atrophic gastritis or gastric cancer with 158 nonatrophic gastritis patients (controls). Conditional logistic regression analysis revealed that an increased risk of atrophic gastritis (odds ratio, 5.60) and gastric cancer (odds ratio, 2.36) was associated with the IL-1B-511 C allele. Our study is the first to establish this allele as a risk for these conditions. Given the high prevalence of H. pylori and recurrence rate after treatment, IL-1B-511 single-nucleotide polymorphism analysis may identify those individuals who would benefit most from robust H. pylori eradication efforts in Peru.
登录
查看更多内容
影响因子：
6.4
作者：
Chang, YW;Jang, JY;Chang, R
通讯作者：
Chang, R
影响因子：
3.8
作者：
Kamangar, Farin;Cheng, Cindy;Rabkin, Charles S.
通讯作者：
Rabkin, Charles S.
影响因子：
3.4
作者：
Doglioni, C;Turrin, M;Barbareschi, M
通讯作者：
Barbareschi, M
影响因子：
11.8
作者：
Bardhan, PK
通讯作者：
Bardhan, PK
影响因子：
5
作者：
Fukui, H;Franceschi, F;Genta, RM
通讯作者：
Genta, RM