The gut microbiota associated with high-Gleason prostate cancer.
The gut microbiota associated with high-Gleason prostate cancer.
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DOI：
10.1111/cas.14998
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发表时间：
2021-08
期刊：
影响因子：
5.7
通讯作者：
Nonomura N
中科院分区：
文献类型：
--
作者：
Matsushita M;Fujita K;Motooka D;Hatano K;Fukae S;Kawamura N;Tomiyama E;Hayashi Y;Banno E;Takao T;Takada S;Yachida S;Uemura H;Nakamura S;Nonomura N
我们发现肠道细菌及其代谢产物短链脂肪酸（SCFAs）促进前列腺癌（PCa）小鼠模型中的癌症生长。为了阐明人类肠道微生物群与PCa之间的关联，我们分析了疑似PCa男性的肠道微生物群特征。研究纳入了152名接受前列腺活检的日本男性（96名患有癌症，56名未患有癌症），并随机分为两个队列：发现队列（114份样本）和测试队列（38份样本）。使用16S rRNA基因测序比较了两组之间的肠道微生物群，即高风险组（2级或更高PCa的男性）和阴性+低风险组（活检阴性或1级PCa的男性）。在高危组中，Rikenellaceae、Alistipes和毛螺菌（所有SCFA产生菌）的相对丰度显著增加。在受试者工作特征曲线分析中，根据通过最小绝对收缩和选择算子回归选择的18种细菌属的丰度计算的指数检测发现队列中的高风险PCa，其准确性高于前列腺特异性抗原检测（曲线下面积[AUC] = 0.85 vs 0.74）。在测试队列中对该指数的验证显示出类似的结果（AUC = 0.81 vs 0.67）。特定的细菌分类群与高风险PCa相关。肠道微生物群特征可能是检测高风险PCa的一种新的有用标志物，并可能有助于PCa的致癌作用。为了阐明肠道微生物群与前列腺癌之间的关系，我们分析了152名接受前列腺活检的男性的肠道微生物群特征。Rikenellaceae，Alistipes和毛螺菌的丰度在患有高风险癌症的男性中显著增加。根据18种细菌属的丰度计算的指数检测出高风险癌症，其准确性高于前列腺特异性抗原检测。
We have found that intestinal bacteria and their metabolites, short‐chain fatty acids (SCFAs), promote cancer growth in prostate cancer (PCa) mouse models. To clarify the association between gut microbiota and PCa in humans, we analyzed the gut microbiota profiles of men with suspected PCa. One hundred and fifty‐two Japanese men undergoing prostate biopsies (96 with cancer and 56 without cancer) were included in the study and randomly divided into two cohorts: a discovery cohort (114 samples) and a test cohort (38 samples). The gut microbiota was compared between two groups, a high‐risk group (men with Grade group 2 or higher PCa) and a negative + low‐risk group (men with negative biopsy or Grade group 1 PCa), using 16S rRNA gene sequencing. The relative abundances of Rikenellaceae, Alistipes, and Lachnospira, all SCFA‐producing bacteria, were significantly increased in high‐risk group. In receiver operating characteristic curve analysis, the index calculated from the abundance of 18 bacterial genera which were selected by least absolute shrinkage and selection operator regression detected high‐risk PCa in the discovery cohort with higher accuracy than the prostate specific antigen test (area under the curve [AUC] = 0.85 vs 0.74). Validation of the index in the test cohort showed similar results (AUC = 0.81 vs 0.67). The specific bacterial taxa were associated with high‐risk PCa. The gut microbiota profile could be a novel useful marker for the detection of high‐risk PCa and could contribute to the carcinogenesis of PCa. To clarify the association between the gut microbiota and prostate cancer, we analyzed the gut microbiota profiles of 152 men undergoing prostate biopsy. The abundances of Rikenellaceae, Alistipes, and Lachnospira were significantly increased in men with high‐risk cancer. The index calculated from the abundance of 18 bacterial genera detected high‐risk cancer with higher accuracy than the prostate specific antigen test.
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影响因子：
3.7
作者：
Miyagi Y;Higashiyama M;Gochi A;Akaike M;Ishikawa T;Miura T;Saruki N;Bando E;Kimura H;Imamura F;Moriyama M;Ikeda I;Chiba A;Oshita F;Imaizumi A;Yamamoto H;Miyano H;Horimoto K;Tochikubo O;Mitsushima T;Yamakado M;Okamoto N
通讯作者：
Okamoto N
DOI：
10.1126/science.1224203
发表时间：
2012-06-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Costello EK;Stagaman K;Dethlefsen L;Bohannan BJ;Relman DA
通讯作者：
Relman DA
影响因子：
4.2
作者：
Li, Fei;Hullar, Meredith A. J.;Lampe, Johanna W.
通讯作者：
Lampe, Johanna W.
影响因子：
56.9
作者：
Gill, Steven R.;Pop, Mihai;Nelson, Karen E.
通讯作者：
Nelson, Karen E.
影响因子：
15.5
作者：
Dai Z;Coker OO;Nakatsu G;Wu WKK;Zhao L;Chen Z;Chan FKL;Kristiansen K;Sung JJY;Wong SH;Yu J
通讯作者：
Yu J