The effects of gonadectomy on sex- and age-typical responses to novelty and ethanol-induced social inhibition in adult male and female Sprague-Dawley rats.
The effects of gonadectomy on sex- and age-typical responses to novelty and ethanol-induced social inhibition in adult male and female Sprague-Dawley rats.
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DOI：
10.1016/j.bbr.2011.10.023
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发表时间：
2012-02-01
影响因子：
2.7
通讯作者：
Spear, Linda P.
中科院分区：
文献类型：
--
作者：
Vetter-O'Hagen, Courtney S.;Spear, Linda P.
对乙醇和新刺激的典型性别和年龄反应往往出现在青春期后，这表明青春期激素在这些行为中具有潜在的组织或激活作用。为了测试这种可能性，雄性和雌性大鼠在出生后第 23 天（早）青春期前或在 P70（晚）成年时被进行性腺切除术 (GX) 或接受假性腺切除术 (SH)。动物在成年后进行了对新奇事物的反应测试，并在第二天在弱光条件下的熟悉环境中与陌生伙伴进行社交互动测试之前，用盐水或乙醇（1g/kg）进行挑战。性腺切除术不会影响乙醇引起的任何性别的社会抑制，而是改变了社会行为的微观结构，无论性腺切除术的年龄如何，GX 动物比 SH 动物表现出较少的社会调查时间和较多的接触行为时间。早期的假手术操作过程本身就影响了社会动机，早期的假手术消除了乙醇引起的两性社会偏好的下降。对新奇事物的反应不受性腺切除术的影响，但与晚期 SH 操作的动物相比，早期受到抑制。这些结果表明，在青春期或成年期，成人对乙醇的典型反应和新奇导向的行为几乎不受性腺激素的影响。然而，发育过程中手术操作的经历本身会产生持续到成年的行为和药理学后果。
Sex- and age-typical responses to ethanol and novel stimuli tend to emerge postpubertally, suggesting a potential organizational or activational role for pubertal hormones in these behaviors. To test this possibility, male and female rats were gonadectomized (GX) or received sham gonadectomy (SH) either prepubertally on postnatal day (P) 23 (early) or in adulthood on P70 (late). Animals were tested as adults for response to novelty and, on the following day, challenged with either saline or ethanol (1g/kg) prior to social interaction testing with an unfamiliar partner in a familiar setting under low light conditions. Gonadectomy did not influence ethanol-induced social inhibition in either sex, but instead altered the microstructure of social behavior, with GX animals exhibiting proportionally less time in social investigation and proportionally more time in contact behavior than SH animals, regardless of age of gonadectomy. The early sham surgical manipulation process itself influenced social motivation, with early SH surgery eliminating ethanol-induced decreases in social preference in both sexes. Response to novelty was unaffected by gonadectomy, but was suppressed in early compared to late SH manipulated animals. These results suggest that adult-typical responses to ethanol and novelty-directed behaviors are little influenced by gonadal hormones during puberty or in adulthood. However, the experience of surgical manipulation itself during development exerts behavioral and pharmacological consequences that last into adulthood.
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影响因子：
2.2
作者：
Cyrenne, De-Laine M.;Brown, Gillian R.
通讯作者：
Brown, Gillian R.
影响因子：
3.4
作者：
Cruz, Fabio C.;Quadros, Isabel M.;Planeta, Cleopatra da S.;Miczek, Klaus A.
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影响因子：
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作者：
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DOI：
10.1111/j.1530-0277.1998.tb03950.x
发表时间：
1998-10-01
影响因子：
3.2
作者：
Roberts, AJ;Smith, AD;Koob, GF
通讯作者：
Koob, GF
DOI：
10.1111/j.1530-0277.2002.tb02585.x
发表时间：
2002-05-01
影响因子：
3.2
作者：
Ford, MM;Eldridge, JC;Samson, HH
通讯作者：
Samson, HH