Effect of Long-Term Sodium Salicylate Administration on Learning, Memory, and Neurogenesis in the Rat Hippocampus.
Effect of Long-Term Sodium Salicylate Administration on Learning, Memory, and Neurogenesis in the Rat Hippocampus.
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长期施用水杨酸钠对大鼠海马学习、记忆和神经发生的影响
DOI：
10.1155/2018/7807426
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发表时间：
2018
影响因子：
--
通讯作者：
Zhang Q
中科院分区：
文献类型：
--
作者：
Niu H;Ding S;Li H;Wei J;Ren C;Wu X;Huma T;Zhang Q
耳鸣被认为是由于暴露于巨大的噪音、老化或其他病因导致的听觉和非听觉系统的损伤引起的。然而，目前，慢性耳鸣的确切神经生理学基础仍不清楚。为探讨耳鸣患者边缘系统功能是否受到干扰，选择在学习记忆中起重要作用的海马作为研究对象。采用学习记忆法检测海马功能。本研究采用水杨酸钠（NaSal）建立大鼠耳鸣动物模型，并以前脉冲抑制行为（PPI）评价。采用Morris水迷宫（MWM）检测实验组和对照组大鼠空间记忆的获得和提取能力，免疫组化法检测海马区c-Fos和delta-FosB蛋白的表达。为了进一步确定耳鸣记忆改变的神经基质，比较了NaSal组和对照组之间齿状回（DG）颗粒下区的神经发生。实验结果表明，NaSal对大鼠空间记忆的获得和提取均有损害作用。在NaSal-treated动物中，c-Fos和delta-FosB蛋白的表达也受到抑制。同时，在DG的神经发生也在耳鸣动物受损。总的来说，我们的数据表明，海马系统（边缘系统）可能在耳鸣病理学中起着关键作用。
Tinnitus is thought to be caused by damage to the auditory and nonauditory system due to exposure to loud noise, aging, or other etiologies. However, at present, the exact neurophysiological basis of chronic tinnitus remains unknown. To explore whether the function of the limbic system is disturbed in tinnitus, the hippocampus was selected, which plays a vital role in learning and memory. The hippocampal function was examined with a learning and memory procedure. For this purpose, sodium salicylate (NaSal) was used to create a rat animal model of tinnitus, evaluated with prepulse inhibition behavior (PPI). The acquisition and retrieval abilities of spatial memory were measured using the Morris water maze (MWM) in NaSal-treated and control animals, followed by observation of c-Fos and delta-FosB protein expression in the hippocampal field by immunohistochemistry. To further identify the neural substrate for memory change in tinnitus, neurogenesis in the subgranular zone of the dentate gyrus (DG) was compared between the NaSal group and the control group. The results showed that acquisition and retrieval of spatial memory were impaired by NaSal treatment. The expression of c-Fos and delta-FosB protein was also inhibited in NaSal-treated animals. Simultaneously, neurogenesis in the DG was also impaired in tinnitus animals. In general, our data suggest that the hippocampal system (limbic system) may play a key role in tinnitus pathology.
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影响因子：
2.7
作者：
Greenwood, Benjamin N.;Foley, Teresa E.;Le, Tony V.;Strong, Paul V.;Loughridge, Alice B.;Day, Heidi E. W.;Fleshner, Monika
通讯作者：
Fleshner, Monika
影响因子：
3.1
作者：
Regensburger M;Prots I;Winner B
通讯作者：
Winner B
影响因子：
56.9
作者：
Frankland, PW;Bontempi, B;Silva, AJ
通讯作者：
Silva, AJ
慢性吗啡暴露后大鼠敏感脑区 NMDA 受体和 FosB/ΔFosB 的表达和共定位
影响因子：
2.5
作者：
Zhang, Qiang;Liu, Qi;Niu, Haichen
通讯作者：
Niu, Haichen
影响因子：
3
作者：
Steube N;Nowotny M;Pilz PK;Gaese BH
通讯作者：
Gaese BH