Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis.
Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis.
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DOI：
10.1016/j.cmet.2010.12.010
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发表时间：
2011-01-05
期刊：
影响因子：
29
通讯作者：
Miguel-Aliaga I
中科院分区：
文献类型：
--
作者：
Cognigni P;Bailey AP;Miguel-Aliaga I
The gastrointestinal tract is emerging as a key regulator of appetite and metabolism, but daunting neuroanatomical complexity has hampered identification of the relevant signals. Invertebrate models could provide a simple and genetically amenable alternative, but their autonomic nervous system and its visceral functions remain largely unexplored. Here we develop a quantitative method based on defecation behavior to uncover a central role for the Drosophila intestine in the regulation of nutrient intake, fluid, and ion balance. We then identify a key homeostatic role for autonomic neurons and hormones, including a brain-gut circuit of insulin-producing neurons modulating appetite, a vasopressin-like system essential for fluid homeostasis, and enteric neurons mediating sex peptide-induced changes in intestinal physiology. These conserved mechanisms of visceral control, analogous to those found in the enteric nervous system and hypothalamic/pituitary axis, enable the study of autonomic control in a model organism that has proved instrumental in understanding sensory and motor systems. ► A metabolic behavior revealing a key homeostatic role for the invertebrate intestine ► Enteric neurons couple reproductive state with intestinal physiology ► An insulinergic brain-gut neuronal circuit adjusts feeding to nutritional conditions ► A vasopressin-like system of central neurons is essential for water homeostasis
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DOI：
10.1073/pnas.0702726104
发表时间：
2007-05-15
影响因子：
11.1
作者：
Ja, William W.;Carvalho, Gil B.;Benzer, Seymour
通讯作者：
Benzer, Seymour
DOI：
10.1073/pnas.1631700100
发表时间：
2003-08-19
影响因子：
11.1
作者：
Liu, HF;Kubli, E
通讯作者：
Kubli, E
卡路里不能通过果蝇饮食限制来解释寿命的延长。
影响因子：
9.8
作者：
Mair, William;Piper, Matthew D W;Partridge, Linda
通讯作者：
Partridge, Linda
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
9.2
作者：
Carvalho, GB;Kapahi, P;Benzer, S
通讯作者：
Benzer, S