A neuronal circuit that generates the temporal motor sequence for the defensive response in zebrafish larvae
A neuronal circuit that generates the temporal motor sequence for the defensive response in zebrafish larvae
复制标题
产生斑马鱼幼虫防御反应的时间运动序列的神经元回路
DOI：
10.1016/j.cub.2021.06.054
复制
发表时间：
2021-07
期刊：
影响因子：
9.2
通讯作者：
Song Jianren
中科院分区：
文献类型：
--
作者：
Xu Lulu;Guan Na N;Huang Chun-Xiao;Hua Yunfeng;Song Jianren
动物使用精确定时的运动序列来逃避捕食者。这需要神经系统协调几种运动行为，并以时间和平滑的方式执行它们。我们在这里描述了一个神经元电路，忠实地产生一个防御运动序列在斑马鱼幼虫。时间特异性防御运动序列由最初的逃避和随后的游泳行为组成，并且可以由单个Mauthner细胞（M细胞）的单侧刺激启动。从逃避行为到游泳行为的平滑过渡是通过激活神经元链回路实现的，该神经元链回路允许M细胞通过激活由相互连接的后脑颅中继神经元形成的中间兴奋回路来驱动双侧内侧纵束核（nMLF）中的下行神经元。通过激活后脑颅中继神经元，双侧nMLF中的M细胞和神经元的顺序激活确保了及时地顺利执行逃避和游泳行为。我们提出了一个串行模型的存在，执行涉及三个不同的大脑区域，启动逃生行为，并触发随后的游泳的时间运动序列。这个模型具有一般意义的神经控制的复杂的运动序列。
Animals use a precisely timed motor sequence to escape predators. This requires the nervous system to coordinate several motor behaviors and execute them in a temporal and smooth manner. We here describe a neuronal circuit that faithfully generates a defensive motor sequence in zebrafish larvae. The temporally specific defensive motor sequence consists of an initial escape and a subsequent swim behavior and can be initiated by unilateral stimulation of a single Mauthner cell (M-cell). The smooth transition from escape behavior to swim behavior is achieved by activating a neuronal chain circuit, which permits an M-cell to drive descending neurons in bilateral nucleus of medial longitudinal fascicle (nMLF) via activation of an intermediate excitatory circuit formed by interconnected hindbrain cranial relay neurons. The sequential activation of M-cells and neurons in bilateral nMLF via activation of hindbrain cranial relay neurons ensures the smooth execution of escape and swim behaviors in a timely manner. We propose an existence of a serial model that executes a temporal motor sequence involving three different brain regions that initiates the escape behavior and triggers a subsequent swim. This model has general implications regarding the neural control of complex motor sequences.
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DOI：
10.1126/science.abb4608
发表时间：
2020-10-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kishore S;Cadoff EB;Agha MA;McLean DL
通讯作者：
McLean DL
影响因子：
64.5
作者：
Egger R;Tupikov Y;Elmaleh M;Katlowitz KA;Benezra SE;Picardo MA;Moll F;Kornfeld J;Jin DZ;Long MA
通讯作者：
Long MA
影响因子：
9.2
作者：
Lacoste, Alix M. B.;Schoppik, David;Robson, Drew N.;Haesemeyer, Martin;Portugues, Ruben;Li, Jennifer M.;Randlett, Owen;Wee, Caroline L.;Engert, Florian;Schier, Alexander F.
通讯作者：
Schier, Alexander F.
影响因子：
5.7
作者：
Jin X;Costa RM
通讯作者：
Costa RM
影响因子：
16.2
作者：
OMalley, DM;Kao, YH;Fetcho, JR
通讯作者：
Fetcho, JR