The molecular basis of neural crest axial identity.
The molecular basis of neural crest axial identity.
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DOI：
10.1016/j.ydbio.2018.07.026
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发表时间：
2018-12-01
影响因子：
2.7
通讯作者：
Simoes-Costa M
中科院分区：
文献类型：
--
作者：
Rothstein M;Bhattacharya D;Simoes-Costa M
神经嵴是一种迁移细胞群，在脊椎动物胚胎发育过程中对多个组织和器官有贡献。它有能力分化成一系列不同的细胞类型，包括黑色素细胞、软骨、骨、平滑肌和周围神经。虽然神经嵴细胞沿着发育中的胚胎的整个前后轴形成，但根据它们的轴向起源水平，它们可以分为不同的亚群。这些细胞群包括颅神经、迷走神经、干神经和骶神经嵴，它们表现出不同的迁移模式，并产生多种衍生物。虽然这些亚种群已被证明大多是可塑的，并根据环境线索进行分化，但它们内在潜力的差异也已被确定。例如，颅神经嵴在形成软骨和骨骼方面的能力是独一无二的。在这里，我们研究了这些发育限制的分子特征，并讨论了不同基因调控网络在这些亚群中运作的假设。我们还考虑了重建躯干和颅神经嵴细胞的系统发育如何影响我们对脊椎动物进化的理解。
The neural crest is a migratory cell population that contributes to multiple tissues and organs during vertebrate embryonic development. It is remarkable in its ability to differentiate into an array of different cell types, including melanocytes, cartilage, bone, smooth muscle, and peripheral nerves. Although neural crest cells are formed along the entire anterior-posterior axis of the developing embryo, they can be divided into distinct subpopulations based on their axial level of origin. These groups of cells, which include the cranial, vagal, trunk, and sacral neural crest, display varied migratory patterns and contribute to multiple derivatives. While these subpopulations have been shown to be mostly plastic and to differentiate according to environmental cues, differences in their intrinsic potentials have also been identified. For instance, the cranial neural crest is unique in its ability to give rise to cartilage and bone. Here, we examine the molecular features that underlie such developmental restrictions and discuss the hypothesis that distinct gene regulatory networks operate in these subpopulations. We also consider how reconstructing the phylogeny of the trunk and cranial neural crest cells impacts our understanding of vertebrate evolution.
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影响因子：
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作者：
COULY, G;COLTEY, P;LEDOUARIN, NM
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LEDOUARIN, NM
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BALLING, R;MUTTER, G;KESSEL, M
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KESSEL, M