TRIM44 promotes human esophageal cancer progression via the AKT/mTOR pathway.
TRIM44 promotes human esophageal cancer progression via the AKT/mTOR pathway.
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TRIM44 通过 AKT/mTOR 通路促进人类食管癌进展
DOI：
10.1111/cas.13762
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发表时间：
2018-10
期刊：
影响因子：
5.7
通讯作者：
Yongbing W
中科院分区：
文献类型：
--
作者：
Xiong D;Jin C;Ye X;Qiu B;Jianjun X;Zhu S;Xiang L;Wu H;Yongbing W
TRIM蛋白44(TRIM44)的异常表达在多种肿瘤中起启动子的作用。本研究旨在探讨TRIM44在人食道癌中的生物学功能及其临床意义。TRIM44在HEC组织中的表达在mRNA水平(2.42±0.52比0.99±0.25)和蛋白水平(1.01±0.27比0.30±0.13)均显著高于相应的正常组织。TRIM44高表达患者分化差(P=1.39×10−5)，临床分期高(P=.87×10−4)，最重要的是预后差(P=2.80×10−5)。TRIM44在上皮间充质转化(EMT)中起重要作用。TRIM44和Ki67的表达呈显著正相关。我们发现TRIM44显著促进HEC细胞的增殖、迁移和侵袭。此外，TRIM44还参与了AKT/mTOR信号通路及其下游靶点，如STAT3的磷酸化。因此，TRIM44的高表达通过AKT/mTOR通路促进EMT促进HEC的发展，TRIM44可能是HEC根治性切除后的一个新的预后指标。
Aberrant expression of TRIM‐containing protein 44 (TRIM44) acts as a promoter in multiple cancers. Here, we investigated the biological functions and clinical significance of TRIM44 in human esophageal cancer (HEC). TRIM44 expression was significantly higher in HEC tissues than corresponding normal tissues at both the mRNA (2.42 ± 0.52 vs 0.99 ± 0.25) and protein (1.01 ± 0.27 vs 0.30 ± 0.13) levels. Patients with high TRIM44 expression showed poor differentiation (P = 1.39 × 10−5), advanced TNM stage (P = 3.87 × 10−4) and, most importantly, significantly poorer prognosis (P = 2.80 × 10−5). TRIM44 played a crucial role in epithelial mesenchymal transition (EMT). A significant correlation was observed between TRIM44 and Ki67 expression. We demonstrated that TRIM44 markedly enhanced HEC cell proliferation, migration, and invasion. Additionally, TRIM44 was involved in the AKT/mTOR signaling pathway and its downstream targets, such as STAT3 phosphorylation. Thus, elevated TRIM44 expression promotes HEC development by EMT via the AKT/mTOR pathway, and TRIM44 may be a novel prognostic indicator for HEC patients after curative resection.
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影响因子：
50.3
作者：
Quante M;Bhagat G;Abrams JA;Marache F;Good P;Lee MD;Lee Y;Friedman R;Asfaha S;Dubeykovskaya Z;Mahmood U;Figueiredo JL;Kitajewski J;Shawber C;Lightdale CJ;Rustgi AK;Wang TC
通讯作者：
Wang TC
影响因子：
254.7
作者：
Siegel, Rebecca;Ma, Jiemin;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
影响因子：
3.4
作者：
Wang, Quan;Wen, Yu-Gang;Peng, Zhi-Hai
通讯作者：
Peng, Zhi-Hai
影响因子：
56.9
作者：
YU, CL;MEYER, DJ;JOVE, R
通讯作者：
JOVE, R
DOI：
10.1016/s0169-328x(00)00281-3
发表时间：
2001-01-31
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Boutou, E;Matsas, R;Mamalaki, A
通讯作者：
Mamalaki, A