Galbut Virus Infection Minimally Influences Drosophila melanogaster Fitness Traits in a Strain and Sex-Dependent Manner.
Galbut Virus Infection Minimally Influences Drosophila melanogaster Fitness Traits in a Strain and Sex-Dependent Manner.
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DOI：
10.3390/v15020539
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发表时间：
2023-02-15
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影响因子：
--
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中科院分区：
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Galbutvirus（Partiviviridae科）感染黑腹果蝇（Drosophila melanogaster），可以从受感染的母亲或受感染的父亲垂直传播，几乎完全有效。这种超孟德尔遗传的形式应该会使感染率达到100%，事实上，在野生D。黑腹种群然而，平均而言，只有约60%的个体苍蝇被感染。一种可能的解释是，一部分苍蝇对感染有抵抗力。虽然感染了大比目鱼病毒的苍蝇看起来很健康，但感染的代价可能足以促使选择耐药宿主，从而降低总体流行率。为了验证这一假设，我们量化了各种健身相关的性状在galbutvirus感染的果蝇从两个线从果蝇遗传参考面板（DGRP）。与未感染的果蝇相比，感染Galbut病毒的果蝇的平均寿命和总后代产量没有差异。Galbut病毒感染的DGRP-517果蝇比未感染的果蝇化蛹和羽化更快。一些感染了大比目鱼病毒的果蝇对病毒、细菌和真菌病原体的敏感性发生了改变。苍蝇的微生物组组成没有受到Galbut病毒感染的可测量干扰。在表型的差异归因于金头病毒感染作为苍蝇的性别和DGRP株的功能而变化，和归因于感染状态的差异相形见绌较大的差异归因于菌株和性别。因此，Galbut病毒感染确实产生可测量的表型变化，变化是微小的，抵消的，并且可能是净阴性的。
Galbut virus (family Partitiviridae) infects Drosophila melanogaster and can be transmitted vertically from infected mothers or infected fathers with near perfect efficiency. This form of super-Mendelian inheritance should drive infection to 100% prevalence, and indeed, galbut virus is ubiquitous in wild D. melanogaster populations. However, on average, only about 60% of individual flies are infected. One possible explanation for this is that a subset of flies are resistant to infection. Although galbut virus-infected flies appear healthy, infection may be sufficiently costly to drive selection for resistant hosts, thereby decreasing overall prevalence. To test this hypothesis, we quantified a variety of fitness-related traits in galbut virus-infected flies from two lines from the Drosophila Genetic Reference Panel (DGRP). Galbut virus-infected flies had no difference in average lifespan and total offspring production compared to their uninfected counterparts. Galbut virus-infected DGRP-517 flies pupated and eclosed faster than their uninfected counterparts. Some galbut virus-infected flies exhibited altered sensitivity to viral, bacterial, and fungal pathogens. The microbiome composition of flies was not measurably perturbed by galbut virus infection. Differences in phenotype attributable to galbut virus infection varied as a function of fly sex and DGRP strain, and differences attributable to infection status were dwarfed by larger differences attributable to strain and sex. Thus, galbut virus infection does produce measurable phenotypic changes, with changes being minor, offsetting, and possibly net-negative.
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DOI：
10.1111/j.1749-6632.1975.tb35099.x
发表时间：
1975-01-01
影响因子：
5.2
作者：
FINE, PEM
通讯作者：
FINE, PEM
影响因子：
5.4
作者：
Cross, Shaun T.;Maertens, Bernadette L.;Stenglein, Mark D.
通讯作者：
Stenglein, Mark D.
影响因子：
5
作者：
Greninger AL
通讯作者：
Greninger AL
影响因子：
14.8
作者：
Apidianakis, Yiorgos;Rahme, Laurence G.
通讯作者：
Rahme, Laurence G.
影响因子：
56.9
作者：
Hedges, Lauren M.;Brownlie, Jeremy C.;Johnson, Karyn N.
通讯作者：
Johnson, Karyn N.