Nanoparticles in the Food Industry and Their Impact on Human Gut Microbiome and Diseases.
Nanoparticles in the Food Industry and Their Impact on Human Gut Microbiome and Diseases.
复制标题
食品工业中的纳米颗粒及其对人类肠道微生物组和疾病的影响。
DOI：
10.3390/ijms22041942
复制
发表时间：
2021-02-16
影响因子：
5.6
通讯作者：
Prakash S
中科院分区：
文献类型：
--
作者：
Ghebretatios M;Schaly S;Prakash S
无机纳米粒子（NPs）的使用已经扩展到包括食品制造、农业、化妆品和建筑在内的各个行业。这使得纳米颗粒能够进入人类胃肠道，但人们对它们如何影响人类健康知之甚少。随着肠道微生物组继续越来越多地参与各种病因不明的疾病，研究人员已经开始研究这些纳米颗粒对肠道微生物组的潜在毒性作用。不幸的是，相互矛盾的结果限制了研究人员评估纳米颗粒对肠道微生物组与健康相关的真正影响的能力。本文综述了五种无机纳米颗粒（银、氧化铁、氧化锌、二氧化钛和二氧化硅）对肠道微生物组和胃肠道的影响，并考虑了文献中的各种方法学差异。这一点很重要，因为NP诱导的肠道变化可能导致各种肠道相关疾病。这些疾病包括肠易激综合征（IBS）、炎症性肠病（IBD）、乳糜泻和结直肠癌。随着慢性胃肠道疾病患者数量的沿着增长，各行业对NP的使用也在不断增加，因此有必要对这一领域进行研究。
The use of inorganic nanoparticles (NPs) has expanded into various industries including food manufacturing, agriculture, cosmetics, and construction. This has allowed NPs access to the human gastrointestinal tract, yet little is known about how they may impact human health. As the gut microbiome continues to be increasingly implicated in various diseases of unknown etiology, researchers have begun studying the potentially toxic effects of these NPs on the gut microbiome. Unfortunately, conflicting results have limited researcher’s ability to evaluate the true impact of NPs on the gut microbiome in relation to health. This review focuses on the impact of five inorganic NPs (silver, iron oxide, zinc oxide, titanium dioxide, and silicon dioxide) on the gut microbiome and gastrointestinal tract with consideration for various methodological differences within the literature. This is important as NP-induced changes to the gut could lead to various gut-related diseases. These include irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), celiac disease, and colorectal cancer. Research in this area is necessary as the use of NPs in various industries continues to grow along with the number of people suffering from chronic gastrointestinal diseases.
登录
查看更多内容
DOI：
10.1002/wnan.1333
发表时间：
2015-09
期刊：
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
影响因子：
--
作者：
Bellmann S;Carlander D;Fasano A;Momcilovic D;Scimeca JA;Waldman WJ;Gombau L;Tsytsikova L;Canady R;Pereira DI;Lefebvre DE
通讯作者：
Lefebvre DE
影响因子：
30.3
作者：
Gevers D;Kugathasan S;Denson LA;Vázquez-Baeza Y;Van Treuren W;Ren B;Schwager E;Knights D;Song SJ;Yassour M;Morgan XC;Kostic AD;Luo C;González A;McDonald D;Haberman Y;Walters T;Baker S;Rosh J;Stephens M;Heyman M;Markowitz J;Baldassano R;Griffiths A;Sylvester F;Mack D;Kim S;Crandall W;Hyams J;Huttenhower C;Knight R;Xavier RJ
通讯作者：
Xavier RJ
影响因子：
5.2
作者：
Feng Y;Min L;Zhang W;Liu J;Hou Z;Chu M;Li L;Shen W;Zhao Y;Zhang H
通讯作者：
Zhang H
影响因子：
3.8
作者：
Agans, Richard T.;Gordon, Alex;Paliy, Oleg
通讯作者：
Paliy, Oleg
影响因子：
4.9
作者：
Andréasson K;Alrawi Z;Persson A;Jönsson G;Marsal J
通讯作者：
Marsal J