Experimental Glaucoma Causes Optic Nerve Head Neural Rim Tissue Compression: A Potentially Important Mechanism of Axon Injury.
Experimental Glaucoma Causes Optic Nerve Head Neural Rim Tissue Compression: A Potentially Important Mechanism of Axon Injury.
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实验性青光眼引起视神经头神经边缘组织压缩：轴突损伤的潜在重要机制。
DOI：
10.1167/iovs.16-20000
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发表时间：
2016-08-01
影响因子：
4.4
通讯作者：
Burgoyne CF
中科院分区：
文献类型：
--
作者：
Fortune B;Reynaud J;Hardin C;Wang L;Sigal IA;Burgoyne CF
我们测试了实验性青光眼（EG）导致视神经乳头（ONH）神经边缘组织比视乳头周围视网膜神经纤维层（RNFL）组织更薄的假设。在基线和单侧EG诱导后，在测压IOP控制（10 mm Hg）下，每隔一周对51只非人灵长类动物（NHP）进行ONH和视乳头周围RNFL的纵向谱域光学相干断层扫描（SDOCT）成像。ONH参数最小边缘面积（MRA）来自以ONH为中心的80个径向B扫描; RNFL横截面积（RNFLA）来自12°直径的乳头周围圆形B扫描。在对照眼中，基线时MRA为1.00 ± 0.19 mm 2，最后一次为1.00 ± 0.19 mm 2（P = 0.77），而RNFLA分别为0.95 ± 0.09和0.95 ± 0.10 mm 2（P = 0.96）。在EG眼中，MRA从基线时的1.00 ± 0.19 mm 2下降到最后一次治疗时的0.63 ± 0.21 mm 2（P < 0.0001），而RNFLA从0.95 ± 0.09下降到0.74 ± 0.19 mm 2（P < 0.0001）。EG眼MRA下降36.4 ± 20.6%，RNFLA下降21.7 ± 19.4%，P < 0.0001。EG眼的其他显著变化包括Bruch膜开口（BMO）非平面性增加（P < 0.05），BMO纵横比减小（P < 0.0001），MRA角度减小（P < 0.001）。对照组或EG组的Bruch膜开口面积与基线相比均无变化（分别为P = 0.27，P = 0.15）。在NHP EG中，视乳头神经边缘组织变薄超过视乳头周围RNFL变薄。这些结果支持了轴突束在ONH边缘内沿沿着横向受压并伴有结缔组织的昏迷性变形的假设。
We tested the hypothesis that experimental glaucoma (EG) results in greater thinning of the optic nerve head (ONH) neural rim tissue than the peripapillary retinal nerve fiber layer (RNFL) tissue. Longitudinal spectral-domain optical coherence tomography (SDOCT) imaging of the ONH and peripapillary RNFL was performed every other week under manometric IOP control (10 mm Hg) in 51 nonhuman primates (NHP) during baseline and after induction of unilateral EG. The ONH parameter minimum rim area (MRA) was derived from 80 radial B-scans centered on the ONH; RNFL cross-sectional area (RNFLA) from a peripapillary circular B-scan with 12° diameter. In control eyes, MRA was 1.00 ± 0.19 mm2 at baseline and 1.00 ± 0.19 mm2 at the final session (P = 0.77), while RNFLA was 0.95 ± 0.09 and 0.95 ± 0.10 mm2, respectively (P = 0.96). In EG eyes, MRA decreased from 1.00 ± 0.19 mm2 at baseline to 0.63 ± 0.21 mm2 at the final session (P < 0.0001), while RNFLA decreased from 0.95 ± 0.09 to 0.74 ± 0.19 mm2, respectively (P < 0.0001). Thus, MRA decreased by 36.4 ± 20.6% in EG eyes, significantly more than the decrease in RNFLA (21.7 ± 19.4%, P < 0.0001). Other significant changes in EG eyes included increased Bruch's membrane opening (BMO) nonplanarity (P < 0.05), decreased BMO aspect ratio (P < 0.0001), and decreased MRA angle (P < 0.001). Bruch's membrane opening area did not change from baseline in either control or EG eyes (P = 0.27, P = 0.15, respectively). Optic nerve head neural rim tissue thinning exceeded peripapillary RNFL thinning in NHP EG. These results support the hypothesis that axon bundles are compressed transversely within the ONH rim along with glaucomatous deformation of connective tissues.
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影响因子：
13.7
作者：
Jia Y;Wei E;Wang X;Zhang X;Morrison JC;Parikh M;Lombardi LH;Gattey DM;Armour RL;Edmunds B;Kraus MF;Fujimoto JG;Huang D
通讯作者：
Huang D
影响因子：
1.9
作者：
Lévêque PM;Zéboulon P;Brasnu E;Baudouin C;Labbé A
通讯作者：
Labbé A
影响因子：
4.4
作者：
Fortune, Brad;Yang, Hongli;Burgoyne, Claude F.
通讯作者：
Burgoyne, Claude F.
影响因子：
4.4
作者：
Cull, Grant;Burgoyne, Claude F.;Wang, Lin
通讯作者：
Wang, Lin
影响因子：
4.4
作者：
He, Lin;Yang, Hongli;Burgoyne, Claude F.
通讯作者：
Burgoyne, Claude F.