The Fog signaling pathway: insights into signaling in morphogenesis.
The Fog signaling pathway: insights into signaling in morphogenesis.
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DOI：
10.1016/j.ydbio.2014.08.003
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发表时间：
2014-10-01
影响因子：
2.7
通讯作者：
Rogers, Stephen L.
中科院分区：
文献类型：
--
作者：
Manning, Alyssa J.;Rogers, Stephen L.
上皮形成许多组织和器官类型的构建块。上皮细胞通常形成连续的二维片层，其通过强粘附保持在一起。由这些粘附赋予的机械性质允许细胞经历戏剧性的三维形态发生运动，同时在胚胎发生和胚胎后发育期间保持细胞-细胞接触。果蝇折叠原肠胚形成途径触发上皮细胞形状变化，从而驱动原肠胚形成和组织折叠，并且是上皮形态发生中研究最广泛的例子之一。这一途径已经产生了关键的见解上皮重塑中涉及的信号机制和细胞机制。在这篇综述中，我们讨论了已发现通过遗传和细胞生物学检查这一途径的形态发生和信号的原则。我们还考虑了各种监管机制和系统的相关性，哺乳动物的发展。我们提出了未来的方向，将继续扩大我们的知识形态发生类群。
Epithelia form the building blocks of many tissue and organ types. Epithelial cells often form a contiguous 2-dimensional sheet that is held together by strong adhesions. The mechanical properties conferred by these adhesions allow the cells to undergo dramatic three-dimensional morphogenetic movements while maintaining cell–cell contacts during embryogenesis and post-embryonic development. The Drosophila Folded gastrulation pathway triggers epithelial cell shape changes that drive gastrulation and tissue folding and is one of the most extensively studied examples of epithelial morphogenesis. This pathway has yielded key insights into the signaling mechanisms and cellular machinery involved in epithelial remodeling. In this review, we discuss principles of morphogenesis and signaling that have been discovered through genetic and cell biological examination of this pathway. We also consider various regulatory mechanisms and the system's relevance to mammalian development. We propose future directions that will continue to broaden our knowledge of morphogenesis across taxa.
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影响因子：
2.9
作者：
Amano, Mutsuki;Nakayama, Masanori;Kaibuchi, Kozo
通讯作者：
Kaibuchi, Kozo
DOI：
10.1073/pnas.88.24.11067
发表时间：
1991-12-01
影响因子：
11.1
作者：
CASSILL, JA;WHITNEY, M;ZUKER, CS
通讯作者：
ZUKER, CS
影响因子：
64.5
作者：
COSTA, M;WILSON, ET;WIESCHAUS, E
通讯作者：
WIESCHAUS, E
影响因子：
10.5
作者：
Häcker, U;Perrimon, N
通讯作者：
Perrimon, N
影响因子：
11.8
作者：
Desprat, Nicolas;Supatto, Willy;Farge, Emmanuel
通讯作者：
Farge, Emmanuel