Osteochondral tissue engineering: scaffolds, stem cells and applications.
Osteochondral tissue engineering: scaffolds, stem cells and applications.
复制标题
DOI：
10.1111/j.1582-4934.2012.01571.x
复制
发表时间：
2012-10
影响因子：
5.3
通讯作者：
Boccaccini AR
中科院分区：
文献类型：
--
作者：
Nooeaid P;Salih V;Beier JP;Boccaccini AR
骨软骨组织工程为修复受损软骨和软骨下骨组织提供了一种新的途径。由于关节软骨自我修复能力的限制，必须开发基于由适当的工程生物材料制成的合适支架的方法。生物可降解聚合物和生物活性陶瓷在各种复合结构中的组合在这一领域是有前途的，由此制造方法、相关细胞和信号传导因子决定了策略的成功。本综述的目的是提出并讨论在骨软骨组织工程中提出的方法，这些方法集中于形成双层复合支架的各种材料的应用，包括聚合物和陶瓷，讨论正在开发的各种支架设计和制造方法。此外，细胞来源和生物蛋白掺入方法进行了讨论，解决他们与支架的相互作用，并强调了创造新一代的双层复合支架，可以模仿天然的界面组织特性，并能够适应生物环境的潜力。
Osteochondral tissue engineering has shown an increasing development to provide suitable strategies for the regeneration of damaged cartilage and underlying subchondral bone tissue. For reasons of the limitation in the capacity of articular cartilage to self-repair, it is essential to develop approaches based on suitable scaffolds made of appropriate engineered biomaterials. The combination of biodegradable polymers and bioactive ceramics in a variety of composite structures is promising in this area, whereby the fabrication methods, associated cells and signalling factors determine the success of the strategies. The objective of this review is to present and discuss approaches being proposed in osteochondral tissue engineering, which are focused on the application of various materials forming bilayered composite scaffolds, including polymers and ceramics, discussing the variety of scaffold designs and fabrication methods being developed. Additionally, cell sources and biological protein incorporation methods are discussed, addressing their interaction with scaffolds and highlighting the potential for creating a new generation of bilayered composite scaffolds that can mimic the native interfacial tissue properties, and are able to adapt to the biological environment.
登录
查看更多内容
骨软骨组织工程双相支架的制备和表征
影响因子：
3
作者：
Bi, Long;Li, Dan;Yuan, Zhi
通讯作者：
Yuan, Zhi
影响因子：
9.7
作者：
Blaker, JJ;Maquet, V;Nazhat, SN
通讯作者：
Nazhat, SN
影响因子：
14
作者：
Chen, QZZ;Thompson, ID;Boccaccini, AR
通讯作者：
Boccaccini, AR
影响因子：
5.3
作者：
Arvidson K;Abdallah BM;Applegate LA;Baldini N;Cenni E;Gomez-Barrena E;Granchi D;Kassem M;Konttinen YT;Mustafa K;Pioletti DP;Sillat T;Finne-Wistrand A
通讯作者：
Finne-Wistrand A
影响因子：
1.6
作者：
Beier, J. P.;Hess, A.;Kneser, U.
通讯作者：
Kneser, U.