Low Intensity Noise Exposure Enhanced Auditory Loudness and Temporal Processing by Increasing Excitability of DCN.
Low Intensity Noise Exposure Enhanced Auditory Loudness and Temporal Processing by Increasing Excitability of DCN.
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DOI：
10.1155/2022/6463355
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发表时间：
2022
影响因子：
3.1
通讯作者：
Sun, Wei
中科院分区：
文献类型：
--
作者：
Shi, Lin;Palmer, Katie;Wang, Haolin;Xu-Friedman, Matthew A.;Sun, Wei
声音刺激通常用于耳鸣和听觉过敏的治疗。最近的研究发现，长期暴露于噪声会改变中枢听觉系统的突触和放电特性，这将通过声惊吓反射检测到。然而，长期低强度声音暴露的感知后果是不清楚的。本研究将检测中等水平噪声暴露（83 dB SPL）对听觉响度的影响，并使用CBA/CaJ小鼠评估时间处理。C-Fos染色检测中枢听觉通路神经元活动的变化。83 dB SPL噪声暴露（每天8小时）两周后，未发现听觉脑干反应（ABR）的持续性阈值偏移。另一方面，噪声暴露显著增强了声惊吓反应（ASR）和间隙诱导的前脉冲抑制（gap-PPI）。根据研究结果，低水平的噪音暴露可以改变时间敏锐度。噪声暴露可使耳蜗背核（DCN）和脑桥尾侧网状核（PnC）的c-Fos阳性神经元数目增加，但对中枢听核团的c-Fos阳性神经元数目无明显影响。我们的研究结果表明，噪声刺激可以改变听觉脑干神经元的兴奋性可能是通过增加的时间处理。
Sound stimulation is generally used for tinnitus and hyperacusis treatment. Recent studies found that long-term noise exposure can change synaptic and firing properties in the central auditory system, which will be detected by the acoustic startle reflex. However, the perceptual consequences of long-term low-intensity sound exposure are indistinct. This study will detect the effects of moderate-level noise exposure (83 dB SPL) on auditory loudness, and temporal processing was evaluated using CBA/CaJ mice. C-Fos staining was used to detect neural activity changes in the central auditory pathway. With two weeks of 83 dB SPL noise exposure (8 hours per day), no persistent threshold shift of the auditory brainstem response (ABR) was identified. On the other hand, noise exposure enhanced the acoustic startle response (ASR) and gap-induced prepulse inhibition significantly (gap-PPI). Low-level noise exposure, according to the findings, can alter temporal acuity. Noise exposure increased the number of c-Fos labeled neurons in the dorsal cochlear nucleus (DCN) and caudal pontine reticular nucleus (PnC) but not at a higher level in the central auditory nuclei. Our results suggested that noise stimulation can change acoustical temporal processing presumably by increasing the excitability of auditory brainstem neurons.
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影响因子：
1.9
作者：
ISON, JR;OCONNOR, K;BOCIRNEA, A
通讯作者：
BOCIRNEA, A
影响因子：
3.7
作者：
Awwad, Bshara;Jankowski, Maciej M.;Nelken, Israel
通讯作者：
Nelken, Israel
影响因子：
2.5
作者：
AITKIN, LM;KENYON, CE;PHILPOTT, P
通讯作者：
PHILPOTT, P
影响因子：
8.2
作者：
Li, Liang;Du, Yi;Wu, Yanhong
通讯作者：
Wu, Yanhong
DOI：
10.1080/10253890290027895
发表时间：
2002-01-01
影响因子：
2.3
作者：
Campeau, Serge;Dolan, David;Watson, Stanley J., Jr.
通讯作者：
Watson, Stanley J., Jr.