Respiration organizes gamma synchrony in the prefronto-thalamic network.

Respiration organizes gamma synchrony in the prefronto-thalamic network.
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呼吸组织在前面 - 丘脑网络中组织伽马同步。

DOI:
10.1038/s41598-023-35516-7
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发表时间:
2023-05-26
期刊:
影响因子:
4.6
通讯作者:
Timofeev, Igor
Timofeev, Igor
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Basha, Diellor;Chauvette, Sylvain;Sheroziya, Maxim;Timofeev, Igor

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多种认知操作与内侧前额叶皮层(mPFC)中伽马振荡的出现有关,尽管对控制这种节律的机制知之甚少。使用当地的场电位记录从猫,我们表明,周期性爆发的伽马复发与1 Hz的规律性唤醒mPFC,并锁定到呼吸周期的呼气相。在mPFC和丘脑(Reu)的结合核之间的伽马波段,呼吸组织了长程相干性,连接了前额叶皮层和海马。小鼠丘脑的体内细胞内记录显示,呼吸计时是通过Reu中的突触活动传播的,并且可能是前额叶皮层中伽马爆发出现的基础。我们的研究结果强调,呼吸是跨前额叶回路(认知操作的关键网络)的长距离神经元同步的重要底物。
Multiple cognitive operations are associated with the emergence of gamma oscillations in the medial prefrontal cortex (mPFC) although little is known about the mechanisms that control this rhythm. Using local field potential recordings from cats, we show that periodic bursts of gamma recur with 1 Hz regularity in the wake mPFC and are locked to the exhalation phase of the respiratory cycle. Respiration organizes long-range coherence in the gamma band between the mPFC and the nucleus reuniens the thalamus (Reu), linking the prefrontal cortex and the hippocampus. In vivo intracellular recordings of the mouse thalamus reveal that respiration timing is propagated by synaptic activity in Reu and likely underlies the emergence of gamma bursts in the prefrontal cortex. Our findings highlight breathing as an important substrate for long-range neuronal synchronization across the prefrontal circuit, a key network for cognitive operations.
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