Basal ganglia beta oscillations accompany cue utilization.
Basal ganglia beta oscillations accompany cue utilization.
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DOI：
10.1016/j.neuron.2011.11.032
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发表时间：
2012-02-09
期刊：
影响因子：
16.2
通讯作者：
Berke JD
中科院分区：
文献类型：
--
作者：
Leventhal DK;Gage GJ;Schmidt R;Pettibone JR;Case AC;Berke JD
皮质基底节 (BG) 回路中的 β 振荡与帕金森病的正常运动抑制和运动障碍有关。为了剖析这些节律的功能相关性，我们比较了大鼠提示选择任务的四种不同变体期间的神经活动。整个皮质-BG 网络同时发生短暂的 beta（~20 Hz）振荡，既自发地发生，又在任务执行的精确时刻发生。贝塔阶段响应显着的线索而迅速重置，但贝塔功率的增加与线索、运动或运动抑制并不严格相关。相反，在使用线索确定运动输出后，贝塔功率得到了增强。我们认为 beta 振荡反映了皮质 BG 网络的决策后稳定状态，这通常会减少来自替代潜在行为的干扰。帕金森病中出现的异常强的β可能反映了这些网络的过度稳定，导致当前运动状态的病理持续性。
Beta oscillations in cortical-basal ganglia (BG) circuits have been implicated in normal movement suppression and motor impairment in Parkinson’s disease. To dissect the functional correlates of these rhythms we compared neural activity during four distinct variants of a cued choice task in rats. Brief beta (~20 Hz) oscillations occurred simultaneously throughout the cortical-BG network, both spontaneously and at precise moments of task performance. Beta phase was rapidly reset in response to salient cues, yet increases in beta power were not rigidly linked to cues, movements, or movement suppression. Rather, beta power was enhanced after cues were used to determine motor output. We suggest that beta oscillations reflect a postdecision stabilized state of cortical-BG networks, which normally reduces interference from alternative potential actions. The abnormally strong beta seen in Parkinson’s Disease may reflect overstabilization of these networks, producing pathological persistence of the current motor state.
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