Fos expression following regimens of predator stress versus footshock that differentially affect prepulse inhibition in rats.
Fos expression following regimens of predator stress versus footshock that differentially affect prepulse inhibition in rats.
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DOI：
10.1016/j.physbeh.2011.08.001
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发表时间：
2011-10-24
影响因子：
2.9
通讯作者：
Bakshi, Vaishali P.
中科院分区：
文献类型：
--
作者：
Baisley, Sarah K.;Cloninger, Christina L.;Bakshi, Vaishali P.
压力被认为会加重精神分裂症和其他几种精神疾病患者的症状，并导致复发。许多这些疾病的一个突出特征是通过感觉运动门控过程过滤信息的能力受损。前脉冲抑制（PPI）是感觉运动门控的功能测量，并且已知在精神分裂症中存在缺陷，有时在创伤后应激障碍（PTSD）中存在缺陷，这两种疾病也对应激诱导的症状恶化敏感。我们以前发现，心理应激源（暴露于雪貂没有身体接触），但不是脚电击，扰乱PPI在大鼠，这表明强烈的心理压力/创伤可能是唯一的模型压力诱导的感觉运动门控异常。在本实验中，我们试图重现我们发现这种行为差异的条件，并探索可能的潜在神经基质。将大鼠急性暴露于雪貂应激、足电击或无应激（对照）。90分钟后，获得用于Fos免疫组织化学的组织以评估神经元活化。几个大脑区域（前边缘，边缘下，扣带皮层，下丘脑室旁核，丘脑室旁核，和外侧导水管周围灰质）同样激活后暴露于任何压力。有趣的是，内侧杏仁核和背内侧中脑导水管周围灰质有近两倍的Fos激活雪貂暴露的大鼠在footshock暴露的大鼠，这表明，这些结构内的较高的激活可能有助于由捕食者应激诱导的独特的行为效应。这些结果可能有影响，了解神经基板，可以参与感觉运动门控异常，在几种精神疾病后，心因性应激。
Stress is suggested to exacerbate symptoms and contribute to relapse in patients with schizophrenia and several other psychiatric disorders. A prominent feature of many of these illnesses is an impaired ability to filter information through sensorimotor gating processes. Prepulse inhibition (PPI) is a functional measure of sensorimotor gating, and known to be deficient in schizophrenia and sometimes in post-traumatic stress disorder (PTSD), both of which are also sensitive to stress-induced symptom deterioration. We previously found that a psychological stressor (exposure to a ferret without physical contact), but not footshock, disrupted PPI in rats, suggesting that intense psychological stress/trauma may uniquely model stress-induced sensorimotor gating abnormalities. In the present experiment, we sought to recreate the conditions where we found this behavioral difference, and to explore possible underlying neural substrates. Rats were exposed acutely to ferret stress, footshock, or no stress (control). 90 minutes later, tissue was obtained for Fos immunohistochemistry to assess neuronal activation. Several brain regions (prelimbic, infralimbic, and cingulate cortices, the paraventricular hypothalamic nucleus, the paraventricular thalamic nucleus, and the lateral periaqueductal gray) were equally activated following exposure to either stressor. Interestingly, the medial amygdala and dorsomedial periaqueductal gray had nearly twice as much Fos activation in the ferret-exposed rats as in the footshock-exposed rats, suggesting that higher activation within these structures may contribute to the unique behavioral effects induced by predator stress. These results may have implications for understanding the neural substrates that could participate in sensorimotor gating abnormalities seen in several psychiatric disorders after psychogenic stress.
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