Amygdala enlargement in unaffected offspring of bipolar parents.
Amygdala enlargement in unaffected offspring of bipolar parents.
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DOI：
10.1016/j.jpsychires.2014.08.023
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发表时间：
2014-12
影响因子：
4.8
通讯作者：
Soares, Jair C.
中科院分区：
文献类型：
--
作者：
Bauer, Isabelle E.;Sanches, Marsal;Suchting, Robert;Green, Charles E.;El Fangary, Nadia M.;Zunta-Soares, Giovana B.;Soares, Jair C.
双相情感障碍(BD)是一种具有很强遗传成分的破坏性疾病。虽然患有BD的个体的额缘轮廓相对较好，但对于未受BD影响的后代的神经解剖学特征仍存在分歧。对82例儿童青少年进行了脑体积测量，其中18例未患BD儿童(10.50±3.37岁)，19例BD精神障碍儿童(12.87±3.28岁)和45例健康对照(Hc-10.50±3.37岁)。根据《精神疾病诊断和统计手册》(DSM-IV)标准进行临床诊断。使用Freesurfer图像分析套件进行皮质重建和体积分割。侧写分析比较了不同组别的额缘体积。将年龄、性别、测试地点、种族和颅内体积作为协变量输入。与患有精神障碍和HC的BD后代相比，未受影响的BD后代右侧杏仁核明显更大。纹状体、海马区、扣带区和颞区的体积在不同组之间具有可比性。杏仁核的大小可能是BD父母后代疾病易感性的一个标志。需要进行纵向研究，以检验转化为BD的比率与特定的发病前脑异常有关。
Bipolar disorder (BD) is a devastating disorder with a strong genetic component. While the frontolimbic profile of individuals suffering from BD is relatively well-established, there is still disagreement over the neuroanatomical features of unaffected BD offspring. Brain volumetric measures were obtained for 82 children and adolescents including 18 unaffected BD offspring (10.50±3.37 years), 19 BD offspring suffering from psychiatric disorders (12.87±3.28 years) and 45 healthy controls (HC-10.50±3.37 years). Clinical diagnoses were established according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria. Cortical reconstruction and volumetric segmentation were performed with the Freesurfer image analysis suite. Profile analyses compared frontolimbic volumes across groups. Age, gender, testing site, ethnicity and intracranial volume were entered as covariates. The right amygdala was significantly larger in unaffected BD offspring compared to BD offspring with psychiatric disorders and HC. Volumes of striatal, hippocampal, cingulate, and temporal regions were comparable across groups. The size of the amygdala may be a marker of disease susceptibility in offspring of BD parents. Longitudinal studies are needed to examine rates of conversion to BD as related to specific pre-morbid brain abnormalities.
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影响因子：
3.7
作者：
Bramen, Jennifer E.;Hranilovich, Jennifer A.;Sowell, Elizabeth R.
通讯作者：
Sowell, Elizabeth R.
影响因子：
--
作者：
Blumberg, HP;Kaufman, J;Peterson, BS
通讯作者：
Peterson, BS
DOI：
10.1097/00004583-200109000-00009
发表时间：
2001-09-01
影响因子：
13.3
作者：
Durston, S;Pol, HEH;van Engeland, H
通讯作者：
van Engeland, H
影响因子：
4
作者：
Delaloye, C.;Moy, G.;Giannakopoulos, P.
通讯作者：
Giannakopoulos, P.
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI