Estrogen receptor-alpha in the bed nucleus of the stria terminalis regulates social affiliation in male prairie voles (Microtus ochrogaster).
Estrogen receptor-alpha in the bed nucleus of the stria terminalis regulates social affiliation in male prairie voles (Microtus ochrogaster).
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DOI：
10.1371/journal.pone.0008931
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发表时间：
2010-01-27
期刊：
影响因子：
3.7
通讯作者：
Kramer KM
中科院分区：
文献类型：
--
作者：
Lei K;Cushing BS;Musatov S;Ogawa S;Kramer KM
雌激素受体α（ERα）通常使男性行为男性化，而内侧杏仁核（MeA）和终纹床核（BST）中ERα水平低与男性亲社会行为水平高相关。在高度社会化的雄性草原田鼠（Microtus ochrogaster）中，MeA中ERα的增加抑制了自发的异源亲行为的表达，并产生了对新雌性的偏好。为了测试BST中增加的ERα的影响，使用病毒载体来增强成年雄性草原田鼠BST中的ERα表达。给药后，对成年雄性动物与1-3日龄幼仔的同种异体父母行为以及异性社会偏好和关系进行了检测。给药未影响异源亲性行为，因为73%的ERα-BST雄性和62.5%的对照雄性为异源亲性。BST中ERα的增加影响了异性恋关系，ERα-BST男性与女性并排接触的总时间显著少于与对照男性接触的时间。ERα-BST雄性动物对熟悉或陌生的雌性动物均未表现出偏好。这些发现与ERα-MeA增强的雄性中报道的结果显著不同，ERα抑制异源亲合行为并产生对新雌性的偏好。这项研究的结果表明了两件事：第一，BST中ERα的增加会减少社会联系，第二，改变社会神经回路不同区域的ERα会不同程度地影响社会行为的表达。
Estrogen receptor alpha (ERα) typically masculinizes male behavior, while low levels of ERα in the medial amygdala (MeA) and the bed nucleus of the stria terminalis (BST) are associated with high levels of male prosocial behavior. In the males of the highly social prairie vole (Microtus ochrogaster), increasing ERα in the MeA inhibited the expression of spontaneous alloparental behavior and produced a preference for novel females. To test for the effects of increased ERα in the BST, a viral vector was used to enhance ERα expression in the BST of adult male prairie voles. Following treatment, adult males were tested for alloparental behavior with 1–3-day-old pups, and for heterosexual social preference and affiliation. Treatment did not affect alloparental behavior as 73% of ERα-BST males and 62.5% of control males were alloparental. Increasing ERα in the BST affected heterosexual affiliation, with ERα-BST males spending significantly less total time in side-by-side contact with females relative to time spent with control males. ERα-BST males did not show a preference for either the familiar or novel female. These findings differed significantly from those reported in ERα-MeA enhanced males, where ERα inhibited alloparental behavior and produced a preference for a novel female. The findings from this study suggest two things: first, that increased ERα in the BST decreases social affiliation and second, that altering ERα in different regions of the social neural circuit differentially impacts the expression of social behavior.
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影响因子：
3.2
作者：
Cushing, BS;Okorie, U;Young, LJ
通讯作者：
Young, LJ
DOI：
10.1073/pnas.93.21.11980
发表时间：
1996-10-15
影响因子：
11.1
作者：
DeVries, AC;DeVries, MB;Carter, CS
通讯作者：
Carter, CS
影响因子：
1.9
作者：
Liu, Y;Curtis, JT;Wang, ZX
通讯作者：
Wang, ZX
影响因子：
2.5
作者：
Gobrogge, Kyle L.;Liu, Yan;Wang, Zuoxin
通讯作者：
Wang, Zuoxin
影响因子：
2.9
作者：
Curtis, JT;Wang, ZX
通讯作者：
Wang, ZX