The effects of pre-test social deprivation on a natural reward incentive test and concomitant 50 kHz ultrasonic vocalization production in adolescent and adult male Sprague-Dawley rats.
The effects of pre-test social deprivation on a natural reward incentive test and concomitant 50 kHz ultrasonic vocalization production in adolescent and adult male Sprague-Dawley rats.
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DOI：
10.1016/j.bbr.2013.02.020
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发表时间：
2013-05-15
影响因子：
2.7
通讯作者：
Spear, Linda P.
中科院分区：
文献类型：
--
作者：
Willey, Amanda R.;Spear, Linda P.
在大鼠中，超声发声(USV)经常被用来衡量情感，其中22 khz的Usv反映负面情绪，50 khz的Usv反映积极情绪。这项研究使用一种改进的奖赏方法任务来评估青春期和成年大鼠在不同数量的预测试社会剥夺后，对食物或社会刺激的行为方法和伴随的USV产生。青少年比成年人花更多的时间研究社会刺激，尽管在社会刺激存在的情况下，隔离居住的成年人比单独居住的青少年发射更多50 khz的紫外线。与测试前接受较少社交隔离的成年人相比，隔离的成年动物会释放更多的USV来进行社会刺激，这种社交剥夺效应在社交方法数据或任何动物接受食物刺激测试的指标中都不明显。当测试食物刺激时，成年人比青少年发射更多的50千赫紫外线，尽管他们花在研究这种刺激上的时间与青少年相同(甚至更少)。总而言之，这些数据表明，50 khz的USV产生和花在研究奖励刺激上的时间显然是分离的，因此似乎衡量了不同的状态。
In rats, ultrasonic vocalizations (USVs) are often used as a measure of affect, with 22 kHz USVs reflecting negative affect and 50 kHz USVs reflecting positive affect. This study used a modified reward approach task to assess behavioral approach and concomitant USV production toward either a food or social stimulus following varied amounts of pre-test social deprivation in both adolescent and adult rats. Adolescents spent significantly more time investigating the social stimulus than adults, although in the presence of the social stimulus isolate housed adults emitted more 50 kHz USVs than isolate housed adolescents. Isolate housed adults emitted more USVs to a social stimulus than adults that received less pre-test social isolation, a social deprivation effect not evident in the social approach data or any measure when animals were tested with a food stimulus. When tested with a food stimulus, adults emitted more 50 kHz USVs than adolescents, although they spent the same (or even less) time investigating that stimulus than did adolescents. Together, these data demonstrate that 50 kHz USV production and time spent investigating a rewarding stimulus are clearly dissociable and hence seemingly measure different states.
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影响因子：
3.6
作者：
Natusch, C.;Schwarting, R. K. W.
通讯作者：
Schwarting, R. K. W.
DOI：
10.1111/j.1749-6632.1997.tb51942.x
发表时间：
1997-01-01
期刊：
INTEGRATIVE NEUROBIOLOGY OF AFFILIATION
影响因子：
--
作者：
Knutson, B;Panksepp, J
通讯作者：
Panksepp, J
影响因子：
1.9
作者：
Burgdorf, J;Knutson, B;Ikemoto, S
通讯作者：
Ikemoto, S
影响因子：
2.5
作者：
Brudzynski, Stefan M.
通讯作者：
Brudzynski, Stefan M.
影响因子：
2.2
作者：
Douglas, LA;Varlinskaya, EI;Spear, LP
通讯作者：
Spear, LP