Childhood trauma history differentiates amygdala response to sad faces within MDD.
Childhood trauma history differentiates amygdala response to sad faces within MDD.
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DOI：
10.1016/j.jpsychires.2010.12.004
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发表时间：
2011-07
影响因子：
4.8
通讯作者：
Shelton R
中科院分区：
文献类型：
--
作者：
Grant MM;Cannistraci C;Hollon SD;Gore J;Shelton R
重度抑郁症患者杏仁核对厌恶性刺激的反应增强被认为是潜在生理学的核心特征，但杏仁核反应的个体差异也可能继发于早期神经发育过程中边缘系统功能相对于应激源（如童年创伤）的持续变化。我们试图确定杏仁核反应增强是否是抑郁症的核心特征或继发于早期生活压力的精神病理学的一般风险因素。20例有或无明显早期生活创伤史的单相抑郁症患者和16例健康对照受试者在一项横断面研究中进行了功能性MRI，比较了悲伤和中性面孔的神经反应。我们观察到身体虐待和右杏仁核反应之间存在强有力的正相关。与其他形式的虐待和忽视的关系也很弱，这表明虐待亚型和杏仁核反应之间的差异。杏仁核反应的组间差异表明，反应增强并不是一般抑郁症患者的特征，但主要是在那些有严重虐待史的人中。这些发现表明，童年创伤与抑郁风险之间的关系是由杏仁核反应增强介导的，但因虐待类型而异。基于创伤史的两种不同抑郁症表型的初步证据也得到了支持，这与不同的病因学是一致的。
Heightened amygdala reactivity to aversive stimuli in major depression is regarded as a core feature of the underlying physiology but individual differences in amygdala response may also arise secondary to persistent changes in limbic function during early neurodevelopment relative to stressors such as childhood trauma. We sought to determine whether heightened amygdala response is a core feature of depression or a general risk factor for psychopathology secondary to early life stress. Twenty unipolar depressed patients with and without a history of significant early life trauma and 16 healthy comparison subjects underwent functional MRI in a cross-sectional study comparing neural response to sad and neutral faces. We observed a robust positive correlation between physical abuse and right amygdala response. A much weaker relationship with other forms of abuse and neglect was also found, suggesting differences between abuse subtypes and amygdala response. Group differences in amygdala response suggest heightened reactivity was not characteristic of persons with depression in general but was true primarily in those with a significant history of abuse. These findings suggest the relationship between childhood trauma and risk for depression is mediated by heightened amygdala response but varies by abuse type. Preliminary evidence for two distinct depression phenotypes based on trauma history was also supported, consistent with differential etiology.
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影响因子：
25
作者：
Mirescu, C;Peters, JD;Gould, E
通讯作者：
Gould, E
影响因子：
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作者：
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通讯作者：
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通讯作者：
Yurgelun-Todd, DA
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作者：
Abercrombie, HC;Schaefer, SM;Davidson, RJ
通讯作者：
Davidson, RJ
影响因子：
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作者：
Parker, KJ;Buckmaster, CL;Lyons, DM
通讯作者：
Lyons, DM