Impact of a pollution breach at a coke oven factory on asthma control in nearby vulnerable adults.
Impact of a pollution breach at a coke oven factory on asthma control in nearby vulnerable adults.
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DOI：
10.1016/j.jaci.2021.04.011
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Fabisiak JP
中科院分区：
文献类型：
--
作者：
Byrwa-Hill BM;Presto AA;Wenzel S;Fabisiak JP
以前的研究表明二氧化硫（SO2）暴露与哮喘急性发作有关。我们利用匹兹堡大学哮喘研究所登记研究了两个地理位置不同的成人哮喘患者人群之间哮喘急性发作的相关性。我们的目的是检查在美国最大的焦炭厂发生重大火灾并摧毁污染控制设备后，哮喘症状是否恶化。两组哮喘患者，即那些居住在10英里内的焦炭厂火灾（近端组[n = 39]）和那些居住在该范围以外（对照组[n = 44]），通过居住地址进行地理编码。使用当地匹兹堡大学哮喘研究所登记的空气监测数据生成环境空气SO2浓度。还对工厂排放进行了评估。对患者历史急性暴露调查数据和亲自随访数据进行了评价。使用推断统计来比较各组。在火灾发生后的6-8周内，工厂排放的SO2排放量增加到典型水平的25倍。污染控制违规后，近端队列自我报告药物使用增加（风险比= 1.76; 95%CI = 1.1-2.8; P <0.01）和更多的急性加重。在仅完成急性暴露调查的一小部分随访队列中，哮喘控制指标得到改善。实际暴露于污染控制违规导致的环境SO2水平显著增加与事件附近患者的哮喘控制恶化相关，控制恶化在控制修复后得到改善。提高空气污染物测量的空间分辨率将有助于更好地检查暴露情况和随后的健康影响。
Previous studies have related sulfur dioxide (SO2) exposure to asthma exacerbations. We utilized the University of Pittsburgh Asthma Institute registry to study associations of asthma exacerbations between 2 geographically distinct populations of adults with asthma. Our objective was to examine whether asthma symptoms worsened following a significant fire event that destroyed pollution control equipment at the largest coke works in the United States. Two groups of patients with asthma, namely, those residing within 10 miles of the coke works fire (the proximal group [n = 39]) and those residing beyond that range (the control group [n = 44]), were geocoded by residential address. Concentrations of ambient air SO2 were generated by using local University of Pittsburgh Asthma Institute registry air monitoring data. Factory emissions were also evaluated. Data from a patient historical acute exposure survey and in-person follow-up data were evaluated. Inferential statistics were used to compare the groups. In the immediate postfire period (6–8 weeks), the level of emissions of SO2 from the factory emissions increased to 25 times more than the typical level. Following the pollution control breach, the proximal cohort self-reported an increase in medication use (risk ratio = 1.76; 95% CI = 1.1–2.8; P < .01) and more exacerbations. In a small subset of the follow-up cohort of those who completed the acute exposure survey only, asthma control metrics improved. Real-world exposure to a marked increase in ambient levels of SO2 from a pollution control breach was associated with worsened asthma control in patients proximal to the event, with the worsened control improving following repair of the controls. Improved spatial resolution of air pollutant measurements would enable better examination of exposures and subsequent health impacts.
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在钢厂附近暴露于空气污染与心率变异性降低有关：一项随机交叉研究。
DOI：
10.1186/s12940-016-0206-0
发表时间：
2017-01-28
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
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通讯作者：
Dales R
影响因子：
2.1
作者：
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通讯作者：
Linn, William S.
影响因子：
5
作者：
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通讯作者：
Casan, Pere
DOI：
10.3961/jpmph.16.037
发表时间：
2016-07-01
期刊：
Journal of preventive medicine and public health = Yebang Uihakhoe chi
影响因子：
--
作者：
Lim, Hyungryul;Kwon, Ho-Jang;Choi, Won-Jun
通讯作者：
Choi, Won-Jun
DOI：
10.3390/ijerph16061057
发表时间：
2019-03-02
影响因子：
--
作者：
Barbone, Fabio;Catelan, Dolores;Biggeri, Annibale
通讯作者：
Biggeri, Annibale