The brain's orienting response (novelty P3) in patients with unilateral temporal lobe resections.
The brain's orienting response (novelty P3) in patients with unilateral temporal lobe resections.
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DOI：
10.1016/j.neuropsychologia.2011.08.023
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发表时间：
2011-10
期刊：
影响因子：
2.6
通讯作者：
Hamberger M
中科院分区：
文献类型：
--
作者：
Friedman D;Nessler D;Kulik J;Hamberger M
大脑的定向反应是一种生物学上原始的，但对生存至关重要的认知功能。虽然基于广泛的大脑区域网络，但外侧前额叶皮层和后海马被认为起着重要作用。事实上，对这些区域的损伤会导致新奇性P3或P3 a的异常，这是定向反应的事件相关电位（ERP）标志。像其他无处不在的定向标记一样，如皮肤电反应，当新事件重复时，P3 a会习惯化。在此，我们评估了接受单侧内侧颞叶（AMTL）前内侧切除术（包括整个海马）以缓解难治性癫痫的患者的P3 a习惯化。8名左AMTL患者和8名右AMTL患者以及16名年龄和教育程度匹配的对照组听到频繁的标准音调，不频繁的目标（需要反应时间）和同样不频繁的独特的新颖环境声音。这部小说在第一次放映后重复了两个街区。在对照组中，新的重复引起P3 a振幅的降低，但这不是在左或右AMTL患者的情况。我们的结论是，双侧完整的前额叶皮层是必要的大脑欣赏一个新的声音的重复发生，也许是由于同侧前额叶皮层-前额叶通路和/或左，右前额叶皮层之间的中断。
The brain’s orienting response is a biologically primitive, yet critical cognitive function necessary for survival. Though based on a wide network of brain regions, the lateral prefrontal cortex and posterior hippocampus are thought to play essential roles. Indeed, damage to these regions results in abnormalities of the novelty P3 or P3a, an event-related potential (ERP) sign of the orienting response. Like other ubiquitous markers of orienting, such as the galvanic skin response, the P3a habituates when novel events are repeated. Here, we assessed habituation of the P3a in patients who had undergone unilateral anteromedial resection of the medial temporal lobe (AMTL), including the entire hippocampus, for relief of pharmacologically intractable epilepsy. Eight left- and 8 right-AMTL patients and 16 age- and education-matched controls heard frequent standard tones, infrequent targets (requiring reaction times) and equally infrequent, unique novel, environmental sounds. The novel sounds repeated 2 blocks after their first presentation. In controls, novel repetition engendered a reduction in P3a amplitude, but this was not the case in either left- or right-AMTL patients. We conclude that bilaterally intact hippocampi are necessary for the brain to appreciate that a repetition of a novel sound has occurred, perhaps due to disruptions in ipsilateral hippocampal-prefrontal pathways and/or between the left and right hippocampi.
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DOI：
10.1016/0168-5597(84)90016-9
发表时间：
1984-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
KNIGHT, RT
通讯作者：
KNIGHT, RT
DOI：
10.1016/0013-4694(95)98475-n
发表时间：
1995-04-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
HALGREN, E;BAUDENA, P;BIRABEN, A
通讯作者：
BIRABEN, A
影响因子：
5.7
作者：
Kiehl, KA;Stevens, MC;Liddle, PF
通讯作者：
Liddle, PF
影响因子：
2.9
作者：
Bidet-Caulet, Aurelie;Ye, Xiao Lai;Bertrand, Olivier
通讯作者：
Bertrand, Olivier
影响因子：
64.8
作者：
Knight, RT
通讯作者：
Knight, RT