Biomonitoring of perfluorinated compounds in children and adults exposed to perfluorooctanoate-contaminated drinking water.
Biomonitoring of perfluorinated compounds in children and adults exposed to perfluorooctanoate-contaminated drinking water.
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DOI：
10.1289/ehp.11064
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发表时间：
2008-05
影响因子：
10.4
通讯作者：
Wilhelm, Michael
中科院分区：
文献类型：
--
作者：
Hoelzer, Juergen;Midasch, Oliver;Rauchfuss, Knut;Kraft, Martin;Reupert, Rolf;Angerer, Juergen;Kleeschulte, Peter;Marschall, Nina;Wilhelm, Michael
德国阿恩斯贝格的4万名居民曾接触过被全氟化合物污染的饮用水。与参考地区相比，评估了阿恩斯贝格居民对六种全氟化学品的内部接触情况。170名儿童（5-6岁），317名母亲（23-49岁）和204名男性（18-69岁）参加了横断面研究。通过问卷调查和访谈评估个人饮用水消耗量和个人特征。采用固相萃取-高效液相色谱-串联质谱法测定血浆中全氟辛酸（PFOA）、全氟辛烷磺酸（PFOS）、全氟己酸、全氟己烷磺酸（PFHxS）、全氟戊酸和全氟丁烷磺酸（PFBS）以及饮用水中PFOA/PFOS。在各种全氟化学品中，全氟辛酸是饮用水中发现的主要化合物（500-640纳克/升）。生活在阿恩斯贝格的居民血浆中的全氟辛酸水平比参考人群高4.5-8.3倍（算术平均值阿恩斯贝格/对照组：儿童24.6/5.2 μg/L，母亲26.7/3.2 μg/L，男子28.5/6.4 μg/L）。在阿恩斯贝格，家中自来水的消耗是PFOA血液浓度的重要预测因子。与对照组相比，阿恩斯贝格的PFHxS浓度显著增加（p < 0.05）。在阿恩斯贝格，PFBS在儿童、妇女和男子中的检出率分别为33%、4%和13%，而在参照地区，分别为5%、0.7%和3%（p < 0.05）。回归分析表明，年龄和男性是全氟辛烷磺酸、全氟辛酸和全氟羟硫化的重要预测因子;其他回归因子（饮食、体重指数）的关联在全氟辛烷磺酸中各不相同。与对照组相比，暴露于PFC污染的饮用水的儿童和成人血浆中PFC浓度增加了4至8倍。
40,000 residents in Arnsberg, Germany, had been exposed to drinking water contaminated with perfluorinated compounds (PFCs). Internal exposure of the residents of Arnsberg to six PFCs was assessed in comparison with reference areas. One hundred seventy children (5–6 years of age), 317 mothers (23–49 years), and 204 men (18–69 years) took part in the cross-sectional study. Individual consumption of drinking water and personal characteristics were assessed by questionnaire and interview. Perfluorooctanoate (PFOA), perfluorooctanesulfonate (PFOS), perfluorohexanoate, perfluorohexanesulfonate (PFHxS), perfluoropentanoate, and perfluorobutanesulfonate (PFBS) in blood plasma and PFOA/PFOS in drinking water samples were measured by solid-phase extraction, high-performance liquid chromatrography, and tandem mass spectrometry detection. Of the various PFCs, PFOA was the main compound found in drinking water (500–640 ng/L). PFOA levels in blood plasma of residents living in Arnsberg were 4.5–8.3 times higher than those for the reference population (arithmetic means Arnsberg/controls: children 24.6/5.2 μg/L, mothers 26.7/3.2 μg/L, men 28.5/6.4 μg/L). Consumption of tap water at home was a significant predictor of PFOA blood concentrations in Arnsberg. PFHxS concentrations were significantly increased in Arnsberg compared with controls (p < 0.05). PFBS was detected in 33% of the children, 4% of the women, and 13% of the men in Arnsberg compared with 5%, 0.7%, and 3%, respectively, in the reference areas (p < 0.05). Regression analysis showed that age and male sex were significant predictors of PFOS, PFOA, and PFHxS; associations of other regressors (diet, body mass index) varied among PFCs. PFC concentrations in blood plasma of children and adults exposed to PFC-contaminated drinking water were increased 4- to 8-fold compared with controls.
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影响因子：
10.4
作者：
Calafat, Antonia M;Wong, Lee-Yang;Kuklenyik, Zsuzsanna;Reidy, John A;Needham, Larry L
通讯作者：
Needham, Larry L
DOI：
10.1097/01.jom.0000233380.13087.37
发表时间：
2006-08-01
影响因子：
3.2
作者：
Emmett, Edward Anthony;Zhang, Hong;Shaw, Leslie Michael
通讯作者：
Shaw, Leslie Michael
影响因子：
8.3
作者：
Ehresman, David J.;Froehlich, John W.;Butenhoff, John L.
通讯作者：
Butenhoff, John L.
DOI：
10.1007/s00420-006-0136-1
发表时间：
2007-02-01
影响因子：
3
作者：
Fromme, H.;Midasch, O.;Liebl, B.
通讯作者：
Liebl, B.
影响因子：
11.4
作者：
Nakata, Haruhiko;Kannan, Kurunthachalam;Takemura, Akira
通讯作者：
Takemura, Akira