Inhibitory effects of sweet cherry anthocyanins on the obesity development in C57BL/6 mice
Inhibitory effects of sweet cherry anthocyanins on the obesity development in C57BL/6 mice
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甜樱桃花青素对C57BL/6小鼠肥胖发展的抑制作用
DOI：
10.3109/09637486.2013.854749
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发表时间：
2014-04
影响因子：
3.9
通讯作者：
Yu Ting
中科院分区：
文献类型：
--
作者：
Wu Tao;Tang Qiong;Yu Zhuoping;Gao Zichun;Hu Hao;Chen Wei;Zheng Xiaodong;Yu Ting
摘要本研究以高脂饲料喂养的雄性C57 BL/6小鼠为实验动物，研究了纯化甜樱桃花青素（CACN）对3 T3-L1细胞脂肪分化的抑制作用及其抗肥胖作用。CACN在C57 BL/6小鼠中预防HFD诱导的肥胖。体内实验表明，饲料中添加40和200 mg/kg的CACN分别使体重下降5.2%和11.2%。补充CACN还可以减少脂肪细胞的大小，瘦素分泌，血清葡萄糖，甘油三酯，总胆固醇，LDL-胆固醇和肝脏甘油三酯。CACN能有效降低IL-6和TNFα基因表达水平，显著提高SOD和GPx活性。我们的研究结果表明，CACN减缓了HFD诱导的雄性C57 BL/6小鼠肥胖的发展。
Abstract In the present study, purified sweet cherry anthocyanins (CACN) were evaluated to determine their inhibitory effects on adipocyte differentiation of 3T3-L1 cells and their anti-obesity properties in male C57BL/6 mice fed with high-fat diet (HFD). CACN prevented HFD-induced obesity in C57BL/6 mice. In vivo experiment revealed that 40 and 200 mg/kg of CACN in food reduced the body weight by 5.2% and 11.2%, respectively. CACN supplementation could also reduce the size of adipocytes, leptin secretion, serum glucose, triglyceride, total cholesterol, LDL-cholesterol and liver triglycerides. Furthermore, CACN could effectively reduce the expression levels of IL-6 and TNFα genes, markedly increase the SOD and GPx activity. Our results indicated that CACN slowed down the development of HFD-induced obesity in male C57BL/6 mice.
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影响因子：
6.1
作者：
Prior, Ronald L.;Wilkes, Samuel E.;Howard, Luke R.
通讯作者：
Howard, Luke R.
影响因子：
5.2
作者：
Prior, Ronald L.;Wu, Xianli;Howard, Luke
通讯作者：
Howard, Luke
影响因子：
8.9
作者：
Martin White
通讯作者：
Martin White
影响因子：
8.1
作者：
S. A. Lenquiste;Â. Batista;R. S. Marineli;N. Dragano;M. Maróstica
通讯作者：
S. A. Lenquiste;Â. Batista;R. S. Marineli;N. Dragano;M. Maróstica
影响因子：
6.1
作者：
Prior, Ronald L.;Wu, Xianli;Howard, Luke R.
通讯作者：
Howard, Luke R.