Novel CaF(2) Nanocomposites with Antibacterial Function and Fluoride and Calcium Ion Release to Inhibit Oral Biofilm and Protect Teeth.
Novel CaF(2) Nanocomposites with Antibacterial Function and Fluoride and Calcium Ion Release to Inhibit Oral Biofilm and Protect Teeth.
复制标题
DOI：
10.3390/jfb11030056
复制
发表时间：
2020-08-01
影响因子：
4.8
通讯作者：
Weir MD
中科院分区：
文献类型：
--
作者：
Mitwalli H;Balhaddad AA;AlSahafi R;Oates TW;Melo MAS;Xu HHK;Weir MD
(1)背景：本研究的目的是开发一种新型的牙科纳米复合材料，该复合材料含有甲基丙烯酸二甲氨基十六酯(DMAHDM)、2-甲基丙烯酰氧乙基磷酰胆碱(MPC)和纳米氟化钙(NCaF2)，通过抗菌、驱避蛋白质和释放氟化物的能力来预防复发的龋病。(2)方法：在双酚A甲基丙烯酸缩水甘油酯(Bis-GMA)和三甘醇二甲基丙烯酸酯(TEGDMA)中分别加入3%MPC、3%DMAHDM和15%nCaF2制备复合材料。测定钙离子和氟离子的释放量。对人唾液的生物膜进行了评估。(3)结果：nCaF2+DMAHDM+MPC复合材料具有最低的生物被膜集落形成单位(CFU)和最大的离子释放量，但其力学性能低于商业对照复合材料(p<；0.05)。NCaF2+DMAHDM复合材料具有类似的生物膜还原能力，其力学性能与商用对照复合材料相当(p>；0.05)。NCaF2+DMAHDM的氟离子和钙离子释放量明显高于商品复合体。复合材料上的生物膜CFU减少4个对数(n=9，p<；0.05)。与商用对照复合体相比，nCaF2+DMAHDM组的生物膜代谢活性和乳酸也显著降低(p<；0.05)。(4)结论：新型纳米复合材料nCaF2+DMAHDM在不影响力学性能的前提下，具有较强的抗菌和离子释放能力。这种生物活性纳米复合材料有望减少生物膜酸的产生，抑制复发的龋齿，并延长修复寿命。
(1) Background: The objective of this study was to develop a novel dental nanocomposite containing dimethylaminohexadecyl methacrylate (DMAHDM), 2-methacryloyloxyethyl phosphorylcholine (MPC), and nanoparticles of calcium fluoride (nCaF2) for preventing recurrent caries via antibacterial, protein repellent and fluoride releasing capabilities. (2) Methods: Composites were made by adding 3% MPC, 3% DMAHDM and 15% nCaF2 into bisphenol A glycidyl dimethacrylate (Bis-GMA) and triethylene glycol dimethacrylate (TEGDMA) (denoted BT). Calcium and fluoride ion releases were evaluated. Biofilms of human saliva were assessed. (3) Results: nCaF2+DMAHDM+MPC composite had the lowest biofilm colony forming units (CFU) and the greatest ion release; however, its mechanical properties were lower than commercial control composite (p < 0.05). nCaF2+DMAHDM composite had similarly potent biofilm reduction, with mechanical properties matching commercial control composite (p > 0.05). Fluoride and calcium ion releases from nCaF2+DMAHDM were much more than commercial composite. Biofilm CFU on composite was reduced by 4 logs (n = 9, p < 0.05). Biofilm metabolic activity and lactic acid were also substantially reduced by nCaF2+DMAHDM, compared to commercial control composite (p < 0.05). (4) Conclusions: The novel nanocomposite nCaF2+DMAHDM achieved strong antibacterial and ion release capabilities, without compromising the mechanical properties. This bioactive nanocomposite is promising to reduce biofilm acid production, inhibit recurrent caries, and increase restoration longevity.
登录
查看更多内容
影响因子：
7.6
作者：
Li, F.;Weir, M. D.;Xu, H. H. K.
通讯作者：
Xu, H. H. K.
影响因子：
8
作者：
Montazeri, N.;Jahandideh, R.;Biazar, Esmaeil
通讯作者：
Biazar, Esmaeil
影响因子：
4.2
作者：
Deng, DM;van Loveren, C;ten Cate, JM
通讯作者：
ten Cate, JM
影响因子：
4.4
作者：
IMAZATO, S;RUSSELL, RRB;MCCABE, JF
通讯作者：
MCCABE, JF
DOI：
10.1073/pnas.1010341107
发表时间：
2010-12-21
影响因子：
11.1
作者：
Beyth, Nurit;Yudovin-Farber, Ira;Weiss, Ervin I.
通讯作者：
Weiss, Ervin I.