COVID-19 Susceptibility in Bronchial Asthma.
COVID-19 Susceptibility in Bronchial Asthma.
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DOI：
10.1016/j.jaip.2020.11.020
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Magen E
中科院分区：
文献类型：
--
作者：
Green I;Merzon E;Vinker S;Golan-Cohen A;Magen E
2019年冠状病毒病(新冠肺炎)中没有对哮喘进行充分评估。呼吸道过敏与血管紧张素转换酶2受体的表达显著减少有关，血管紧张素转换酶2是新冠肺炎的进入受体。为观察新冠肺炎在哮喘患者中的易感性，分析在连续的门诊队列中进行新冠肺炎检测的大样本中哮喘的患病率。这是一项基于人群的回溯性横断面研究，使用了以色列一家大型全国性健康维护组织的数据。纳入2020年2月至6月期间接受新冠肺炎检测的所有健康维护组织注册人员。分析新冠肺炎逆转录聚合酶链式反应阴性与阳性以及新冠肺炎逆转录聚合酶链式反应阳性伴与不伴哮喘的人口学和临床特征的差异。共检测37,469人新冠肺炎，其中2,266人(6.05%)为阳性。新冠肺炎阴性组的吸烟者比例显著高于新冠肺炎阳性组(4734[13.45%]vs103[4.55%]；P<；.001)。新冠肺炎阳性组153例(6.75%)和新冠肺炎阴性组3,388例(9.62%)发生哮喘(P<；.001)。抗白三烯、吸入性皮质类固醇和长效β-受体阻滞剂的使用对新冠肺炎阳性比例没有显著影响。经性别、年龄、吸烟和合并症校正后的多元Logistic回归分析显示，哮喘与新冠肺炎阳性的可能性呈负相关(优势比，0.71；95%可信区间，0.58-0.87；P=.001)。我们观察到既往存在哮喘的患者新冠肺炎易感性较低。
Bronchial asthma has not been adequately assessed in coronavirus disease 2019 (COVID-19). Respiratory allergy is associated with significant reductions in the expression of angiotensin-converting enzyme 2 receptor, which is the entry receptor for COVID-19. To observe COVID-19 susceptibility in patients with bronchial asthma, analyze the prevalence of asthma in a large cohort of consecutive outpatient subjects who were tested with the RT-PCR assay for COVID-19. This was a retrospective population-based cross-sectional study using data from a large nationwide health maintenance organization in Israel. All health maintenance organization enrollees who had been tested for COVID-19 from February to June 2020 were included. Differences in demographic and clinical characteristics between the subjects with negative and positive COVID-19 RT-PCR test results and between COVID-19 RT-PCR–positive subjects with and without asthma were analyzed. A total of 37,469 subjects were tested for COVID-19 RT-PCR, and results for 2,266 (6.05%) of them were positive. A significantly higher proportion of smokers was observed in the COVID-19–negative group than in the COVID-19–positive group (4734 [13.45%] vs 103 [4.55%]; P < .001). Asthma was found in 153 (6.75 %) subjects of the COVID-19–positive group and in 3388 (9.62%) subjects of the COVID-19–negative group (P < .001). No significant impact of antileukotrienes, inhaled corticosteroids, and long-acting beta-blockers use was revealed on COVID-19 positivity proportions. Multiple logistic regression analysis adjusted for sex, age, smoking, and comorbidity revealed a negative association of asthma with the likelihood of being positive for COVID-19 (odds ratio, 0.71; 95% CI, 0.58-0.87; P = .001). We observed lower COVID-19 susceptibility in patients with preexisting asthma.
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影响因子：
6.9
作者：
Malavazos, Alexis Elias;Romanelli, Massimiliano Marco Corsi;Iacobellis, Gianluca
通讯作者：
Iacobellis, Gianluca
影响因子：
28.3
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影响因子：
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作者：
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DOI：
10.1016/j.jaip.2020.06.001
发表时间：
2020-09-01
影响因子：
9.4
作者：
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通讯作者：
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影响因子：
2
作者：
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通讯作者：
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