Housing environment modulates physiological and behavioral responses to anxiogenic stimuli in trait anxiety male rats.
Housing environment modulates physiological and behavioral responses to anxiogenic stimuli in trait anxiety male rats.
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DOI：
10.1016/j.neuroscience.2014.03.060
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发表时间：
2014-06-13
期刊：
影响因子：
3.3
通讯作者：
Donaldson ST
中科院分区：
文献类型：
--
作者：
Ravenelle R;Santolucito HB;Byrnes EM;Byrnes JJ;Donaldson ST
丰富的环境可以调节轻度和慢性应激，对焦虑刺激的反应以及在一些动物模型中的药物易感性。本研究旨在研究出生后环境丰富对选择性繁殖的第4代高（HAn）和低焦虑（LAn）雄性大鼠的影响。断奶后，将动物置于隔离的、群居的和丰富的环境中（例如，玩具、轮子、绳子，每周更换一次）。我们测量了高架十字迷宫上的焦虑样行为（ALB;试验1在PND 46，试验2在PND 63），安非他明（0.5 mg/kg，IP）诱导的运动行为，基础和致焦虑刺激后（1）血浆皮质酮，（2）血压和（3）核心体温的变化。最初，动物表现出一致的性状差异与HAn显示更多的ALB，但40天后，在选择住房，HAn大鼠饲养在丰富的环境（EE）显示较少的ALB和减少AMPH诱导的活动相比，HAn动物在隔离（IE）和社会环境（SE）。在生理学测试中，EE中饲养的动物显示出对强制性新物体暴露的肾上腺皮质反应升高，但在空气抽吸应激源后体温和血压变化降低。在EE和SE饲养的所有动物在中央杏仁核（CeA），CA 1和CA 2海马区和尾壳核中的BDNF阳性细胞升高，但这些差异在HAn大鼠CeA，CA 1和CA 2中最为明显。总体而言，这些研究结果表明，丰富的环境为特质焦虑大鼠提供了好处，包括减少对焦虑刺激和安非他明敏感性的行为和生理反应，这些反应与中央杏仁核，海马和尾壳核中BDNF表达的变化相关。
Environmental enrichment can modulate mild and chronic stress, responses to anxiogenic stimuli as well as drug vulnerability in a number of animal models. The current study was designed to examine the impact of postnatal environmental enrichment on selectively bred 4th generation high (HAn) and low anxiety (LAn) male rats. After weaning, animals were placed in isolated, social and enriched environments (e.g., toys, wheels, ropes, changed weekly). We measured anxiety-like behavior (ALB) on the elevated plus maze (EPM; trial 1 at PND 46, trial 2 at PND 63), amphetamine (0.5 mg/kg, IP)-induced locomotor behavior, basal and post anxiogenic stimuli changes in (1) plasma corticosterone, (2) blood pressure and (3) core body temperature. Initially, animals showed consistent trait differences on EPM with HAn showing more ALB but after 40 days in select housing, HAn rats reared in an enriched environment (EE) showed less ALB and diminished AMPH-induced activity compared to HAn animals housed in isolated (IE) and social environments (SE). In the physiological tests, animals housed in EE showed elevated adrenocortical responses to forced novel object exposure but decreased body temperature and blood pressure changes after an air puff stressor. All animals reared in EE and SE had elevated BDNF-positive cells in the central amygdala (CeA), CA1 and CA2 hippocampal regions and the caudate putamen, but these differences were most pronounced in HAn rats for CeA, CA1 and CA2. Overall, these findings suggest that environmental enrichment offers benefits for trait anxiety rats including a reduction in behavioral and physiological responses to anxiogenic stimuli and amphetamine sensitivity, and these responses correlate with changes in BDNF expression in the central amygdala, hippocampus and the caudate putamen.
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