The microbiome and mosquito vectorial capacity: rich potential for discovery and translation.
The microbiome and mosquito vectorial capacity: rich potential for discovery and translation.
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DOI：
10.1186/s40168-021-01073-2
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发表时间：
2021-05-18
期刊：
影响因子：
15.5
通讯作者：
Hughes GL
中科院分区：
文献类型：
--
作者：
Cansado-Utrilla C;Zhao SY;McCall PJ;Coon KL;Hughes GL
微生物组研究由于其对人类和动物健康影响的新证据而获得了相当大的兴趣。与其他动物一样，蚊子的肠道相关微生物群影响宿主的适应性和其他表型。现在已经确定，微生物可以积极或消极地改变病原体在蚊子中的传播，并且正在探索利用微生物进行媒介控制的途径。然而，很少有人关注微生物群如何影响影响载体能力的表型。媒介密度、叮咬率、存活率、媒介能力、病原体外源潜伏期等蚊媒和病原体组成因素均影响病原体的传播。最近的研究还表明，与蚊子肠道相关的微生物可以影响这些成分中的每一个，从而最终调节媒介能力。有希望的是，这扩大了利用微生物控制病媒的选择，也针对影响病媒能力的参数。然而，为了有效地利用它们，关于蚊子-微生物相互作用仍有许多知识空白需要解决。在这里，我们回顾了微生物组对媒介能力方面影响的现有证据，并强调了新的媒介控制策略和需要进一步研究的领域的可能机会。视频摘要在线版本包含补充材料，可在10.1186/s40168-021-01073-2获得。
Microbiome research has gained considerable interest due to the emerging evidence of its impact on human and animal health. As in other animals, the gut-associated microbiota of mosquitoes affect host fitness and other phenotypes. It is now well established that microbes can alter pathogen transmission in mosquitoes, either positively or negatively, and avenues are being explored to exploit microbes for vector control. However, less attention has been paid to how microbiota affect phenotypes that impact vectorial capacity. Several mosquito and pathogen components, such as vector density, biting rate, survival, vector competence, and the pathogen extrinsic incubation period all influence pathogen transmission. Recent studies also indicate that mosquito gut-associated microbes can impact each of these components, and therefore ultimately modulate vectorial capacity. Promisingly, this expands the options available to exploit microbes for vector control by also targeting parameters that affect vectorial capacity. However, there are still many knowledge gaps regarding mosquito–microbe interactions that need to be addressed in order to exploit them efficiently. Here, we review current evidence of impacts of the microbiome on aspects of vectorial capacity, and we highlight likely opportunities for novel vector control strategies and areas where further studies are required. Video abstract The online version contains supplementary material available at 10.1186/s40168-021-01073-2.
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