Development of a high efficiency dry powder inhaler: effects of capsule chamber design and inhaler surface modifications.
Development of a high efficiency dry powder inhaler: effects of capsule chamber design and inhaler surface modifications.
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DOI：
10.1007/s11095-013-1165-6
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发表时间：
2014-02
影响因子：
3.7
通讯作者：
Longest, P. Worth
中科院分区：
文献类型：
--
作者：
Behara, Srinivas R. B.;Farkas, Dale R.;Hindle, Michael;Longest, P. Worth
关键词：
本研究的目的是根据胶囊方向的变化以及胶囊和器械的表面改性，探索用于赋形剂增强生长（EEG）气雾剂递送的高效干粉吸入器（DPI）的性能。DPI构建新设计的胶囊室（CC）与先前开发的三维（3D）棒阵列的颗粒解聚和先前优化的EEG制剂相结合。新的CC使胶囊垂直于进入的气流定向，并在整个设备的恒定压降下针对不同的空气入口进行分析。对吸入器和胶囊表面的修改包括使用金属分散棒和表面涂层。对新型DPI的雾化性能进行了评价，并与商业装置进行了比较。建议胶囊的方向和运动模式增加胶囊的振动频率和减少气溶胶MMAD相比，商业/修改DPI。在3D阵列中使用金属棒进一步改善了吸入器性能。用PTFE涂覆吸入器和胶囊显著增加了优化DPI的发射剂量（艾德）。使用优化的DPI装置和制剂组合实现了EEG输送的高效性能，产生了MMAD < 1.5 µm、FPF<5µm/艾德> 90%和艾德> 80%的气雾剂。
The objective of this study was to explore the performance of a high efficiency dry powder inhaler (DPI) intended for excipient enhanced growth (EEG) aerosol delivery based on changes to the capsule orientation and surface modifications of the capsule and device. DPIs were constructed by combining newly designed capsule chambers (CC) with a previously developed three-dimensional (3D) rod array for particle deagglomeration and a previously optimized EEG formulation. The new CCs oriented the capsule perpendicular to the incoming airflow and were analyzed for different air inlets at a constant pressure drop across the device. Modifications to the inhaler and capsule surfaces included use of metal dispersion rods and surface coatings. Aerosolization performance of the new DPIs was evaluated and compared with commercial devices. The proposed capsule orientation and motion pattern increased capsule vibrational frequency and reduced the aerosol MMAD compared with commercial/modified DPIs. The use of metal rods in the 3D array further improved inhaler performance. Coating the inhaler and capsule with PTFE significantly increased emitted dose (ED) from the optimized DPI. High efficiency performance is achieved for EEG delivery with the optimized DPI device and formulation combination producing an aerosol with MMAD < 1.5 µm, FPF<5µm/ED > 90%, and ED > 80%.
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影响因子：
3.7
作者：
Coates, MS;Fletcher, DF;Raper, JA
通讯作者：
Raper, JA
影响因子：
4.7
作者：
Behara, Srinivas Ravindra Babu;Kippax, Paul;Stewart, Peter
通讯作者：
Stewart, Peter
影响因子：
5.8
作者：
Heng, Desmond;Lee, Sie Huey;Tan, Reginald B. H.
通讯作者：
Tan, Reginald B. H.
DOI：
10.1089/jamp.2012.0975
发表时间：
2013-06-01
影响因子：
3.4
作者：
Delvadia, Renishkumar;Hindle, Michael;Byron, Peter R.
通讯作者：
Byron, Peter R.
DOI：
10.1111/j.2042-7158.2012.01476.x
发表时间：
2012-09
期刊：
The Journal of pharmacy and pharmacology
影响因子：
--
作者：
Hindle M;Longest PW
通讯作者：
Longest PW