Monitoring Human Exposure to Organophosphate Esters: Comparing Silicone Wristbands with Spot Urine Samples as Predictors of Internal Dose.
Monitoring Human Exposure to Organophosphate Esters: Comparing Silicone Wristbands with Spot Urine Samples as Predictors of Internal Dose.
复制标题
监测人体暴露于有机磷酸酯：比较硅胶腕带与现场尿样作为内部剂量的预测因素。
DOI：
10.1021/acs.estlett.1c00629
复制
发表时间：
2021-09-14
影响因子：
10.9
通讯作者：
Stapleton, Heather M.
中科院分区：
文献类型：
--
作者：
Hoffman, Kate;Levasseur, Jessica L.;Zhang, Sharon;Hay, Duncan;Herkert, Nicholas J.;Stapleton, Heather M.
硅胶腕带提供了一种无创暴露评估工具和传统生物监测的替代方案；然而，由于验证研究有限，对其实用性的疑问仍然存在。我们试图确定腕带是否能够定量估计体内有机磷酸酯 (OPE) 暴露量。我们通过测量 10 名成年人五天内收集的 24 小时尿液样本中排出的代谢物质量来评估内部剂量。我们将内部剂量与采集过程中佩戴的配对腕带中的 OPE 浓度进行了比较，并作为比较评估了点尿样本中的代谢水平。所评估的 6 种 OPE 代谢物中的 3 种在 > 98% 的尿液样本中检测到，而 34 种评估的 OPE 中的 24 种在至少一个腕带中被检测到。腕带中 OPE 的吸收随时间呈线性关系（范围=0.54-61.8 ng/g/天）。点尿和腕带中的 OPE 浓度与尿液中排泄的总磷酸二苯酯 (DPHP) 不相关，这可能是由于可能的 DPHP 母体化合物范围或饮食暴露所致。然而，对于磷酸三（1,3-二氯-2-丙基）酯（TDCIPP）和磷酸三（2-氯异丙基）酯（TCIPP），腕带和点尿样本均与内部剂量呈中度至强相关（所有rs>0.56且p<0.1），表明两者在综合暴露估计方面表现良好。鉴于硅胶腕带的潜在优势，有必要进一步研究其他化合物。
Silicone wristbands present a noninvasive exposure assessment tool and an alternative to traditional biomonitoring; however, questions about their utility remain as validation studies are limited. We sought to determine if wristbands provide quantitative estimates of internal organophosphate ester (OPE) exposure. We evaluated internal dose by measuring metabolite masses excreted in 24-hour urine samples collected over five days among ten adults. We compared internal dose to OPE concentrations in paired wristbands worn during collection and, as a comparison, evaluated metabolite levels in spot urine samples. Three of six OPE metabolites evaluated were detected in >98% of urine samples, and 24 of 34 assessed OPEs were detected in at least one wristband. OPE uptake in wristbands was linear over time (range=0.54-61.8 ng/g/day). OPE concentrations in spot urine and wristbands were not correlated with total diphenyl phosphate (DPHP) excreted in urine, which may be due to the range of possible DPHP parent compounds or dietary exposure. However, for tris-(1,3-dichloro-2-propyl)phosphate (TDCIPP) and tris-(2-chloroisopropyl)phosphate (TCIPP), wristbands and spot urine samples were both moderately to strongly correlated with internal dose (all rs>0.56 and p<0.1), suggesting both perform well as integrated exposure estimates. Given the potential advantages of silicone wristbands, further studies investigating additional compounds are warranted.
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影响因子：
8.3
作者：
Dobraca D;Lum R;Sjödin A;Calafat AM;Laurent CA;Kushi LH;Windham GC
通讯作者：
Windham GC
影响因子：
11.4
作者：
Hammel SC;Phillips AL;Hoffman K;Stapleton HM
通讯作者：
Stapleton HM
影响因子：
11.4
作者：
Hammel SC;Hoffman K;Webster TF;Anderson KA;Stapleton HM
通讯作者：
Stapleton HM
影响因子：
4.3
作者：
Dixon HM;Scott RP;Holmes D;Calero L;Kincl LD;Waters KM;Camann DE;Calafat AM;Herbstman JB;Anderson KA
通讯作者：
Anderson KA
影响因子：
11.8
作者：
Phillips AL;Hammel SC;Hoffman K;Lorenzo AM;Chen A;Webster TF;Stapleton HM
通讯作者：
Stapleton HM