Evolving trends in the prevalence of hepatitis C virus antibody positivity among HIV-infected men in a community-based primary care setting.
Evolving trends in the prevalence of hepatitis C virus antibody positivity among HIV-infected men in a community-based primary care setting.
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DOI：
10.1111/jvh.13354
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发表时间：
2020-11
影响因子：
2.5
通讯作者：
Wiberg KJ
中科院分区：
文献类型：
--
作者：
Chen YC;Thio CL;Kamangar F;Cox AL;Wiberg KJ
美国的丙型肝炎病毒（HCV）感染主要发生在1945-1965年间出生的人中。然而，近年来新的感染继续增加。为了了解男性艾滋病病毒感染者中不同年龄和风险人群HCV感染的患病率和危险因素的变化，我们对2003年至2014年马里兰州城市/郊区和农村多地点社区卫生中心的1948名艾滋病病毒感染者进行了回顾性横断面分析。我们使用多变量逻辑回归来确定与HCV抗体（抗-HCV）阳性相关的因素，并使用限制性三次样条方法来模拟抗-HCV患病率随时间的趋势。总抗-HCV感染率为24.2%。在整个队列中，年患病率从2003年的38%下降到2014年的24%，并且在≥40岁的人群中。然而，在较年轻（<40岁）或注射吸毒和（或）与男性发生性关系的男性群体中，年流行率最初有所上升，然后趋于稳定。在较年轻的注射吸毒者中，流行率从2003年的33%上升到2009年的79%，然后趋于稳定。抗-HCV阳性的独立预测因素在有和没有注射毒品使用的男性之间以及在<40岁和≥40岁的男性之间存在差异。值得注意的是，在居住在农村地区的年轻白色注射吸毒者中观察到抗-HCV的高流行率。因此，在这一多样化的HIV感染男性人群中，HCV的流行在高危人群中继续有增无减。HCV在年轻的HIV感染者中的持续传播对HCV的根除构成了挑战。
Hepatitis C virus (HCV) infections in the United States occurred mostly among those born between 1945–1965. However, new infections continue to increase in recent years. To understand the changes in the prevalence and risk factors of HCV infection in different age and risk groups among men living with HIV, we performed a retrospective cross-sectional analyses of 1948 HIV-infected men at a multisite community health center in urban/suburban and rural Maryland from 2003 through 2014. We used multivariate logistic regression to determine factors associated with HCV antibody (anti-HCV) positivity and restricted cubic spline method to model trends in anti-HCV prevalence over time. The overall anti-HCV prevalence was 24.2%. The annual prevalence declined in the full cohort, from 38% in 2003 to 24% in 2014, and among those ≥40 years old. However, the annual prevalence increased initially and then stabilized in the groups of men who were younger (<40 years old) or had injection-drug use and/or sex with men. Among the younger injection-drug users, the prevalence rose from 33% in 2003 to 79% in 2009 and then stabilized. The independent predictors for anti-HCV positivity differed between the men with and without injection-drug use and between those <40 and ≥40 years old. Notably, a high prevalence of anti-HCV was observed among the younger, white injection-drug users residing in rural areas. Thus, the HCV epidemic continued unabated among high-risk individuals in this diverse population of HIV-infected men. The ongoing HCV transmission among young HIV-infected men poses a challenge en route to HCV eradication.
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影响因子：
2.5
作者：
Seaberg EC;Witt MD;Jacobson LP;Detels R;Rinaldo CR;Young S;Phair JP;Thio CL
通讯作者：
Thio CL
影响因子：
11.8
作者：
Moorman, Anne C.;Gordon, Stuart C.;Holmberg, Scott D.
通讯作者：
Holmberg, Scott D.
影响因子：
39.2
作者：
Denniston MM;Jiles RB;Drobeniuc J;Klevens RM;Ward JW;McQuillan GM;Holmberg SD
通讯作者：
Holmberg SD
影响因子：
11.8
作者：
Klevens, R. Monina;Hu, Dale J.;Holmberg, Scott D.
通讯作者：
Holmberg, Scott D.
影响因子：
11.8
作者：
Sherman, KE;Rouster, SD;Rajicic, N
通讯作者：
Rajicic, N