NSDNA: a manually curated database of experimentally supported ncRNAs associated with nervous system diseases.

NSDNA: a manually curated database of experimentally supported ncRNAs associated with nervous system diseases.
复制标题

NSDNA:手动管理的数据库,包含与神经系统疾病相关的实验支持的 ncRNA

DOI:
10.1093/nar/gkw1038
复制
发表时间:
2017-01-04
影响因子:
14.9
通讯作者:
Wang L
Wang L
中科院分区:
生物学2区
文献类型:
--
作者:
Wang J;Cao Y;Zhang H;Wang T;Tian Q;Lu X;Lu X;Kong X;Liu Z;Wang N;Zhang S;Ma H;Ning S;Wang L

文献摘要

参考文献

被引文献

相似文献

神经系统疾病NcRNAome图谱(NSDNA)(http://www.bio-bigdata.net/nsdna/)是一个人工管理的数据库,提供了关于神经系统疾病(NSD)和非编码RNA(ncRNA)的全面实验支持的关联。NSD是一组常见的疾病,其中一些具有高发病率和残疾的特点。NSD在分子水平上的发病机制仍然知之甚少。ncRNA是功能上重要的RNA分子的大家族。越来越多的证据表明,不同的ncRNA在各种NSD中起着关键作用。挖掘和总结NSD-ncRNA关联数据可以帮助研究人员发现有用的信息。因此,我们开发了一个NSDNA数据库,该数据库记录了11个物种中142个NSD和8593个ncRNA之间的24713个关联,来自1300多篇文章。该数据库提供了一个方便用户浏览和搜索的界面,并允许灵活地下载数据。此外,NSDNA还提供了一个提交页面,供研究人员提交新的NSD-ncRNA关联。它代表了一个非常有用和宝贵的资源,为研究人员谁寻求了解的功能和参与NSD的ncRNA的分子机制。
The Nervous System Disease NcRNAome Atlas (NSDNA) (http://www.bio-bigdata.net/nsdna/) is a manually curated database that provides comprehensive experimentally supported associations about nervous system diseases (NSDs) and noncoding RNAs (ncRNAs). NSDs represent a common group of disorders, some of which are characterized by high morbidity and disabilities. The pathogenesis of NSDs at the molecular level remains poorly understood. ncRNAs are a large family of functionally important RNA molecules. Increasing evidence shows that diverse ncRNAs play a critical role in various NSDs. Mining and summarizing NSD–ncRNA association data can help researchers discover useful information. Hence, we developed an NSDNA database that documents 24 713 associations between 142 NSDs and 8593 ncRNAs in 11 species, curated from more than 1300 articles. This database provides a user-friendly interface for browsing and searching and allows for data downloading flexibility. In addition, NSDNA offers a submission page for researchers to submit novel NSD–ncRNA associations. It represents an extremely useful and valuable resource for researchers who seek to understand the functions and molecular mechanisms of ncRNA involved in NSDs.
DOI: 10.1093/nar/gks1042
发表时间: 2013-01
影响因子: 14.9
作者:
Sunkin SM;Ng L;Lau C;Dolbeare T;Gilbert TL;Thompson CL;Hawrylycz M;Dang C
通讯作者: Dang C
DOI: 10.1093/nar/gkn770
发表时间: 2009-01
影响因子: 14.9
作者:
Tang S;Zhang Z;Kavitha G;Tan EK;Ng SK
通讯作者: Ng SK
DOI: 10.1016/j.neuron.2015.12.008
发表时间: 2016-01-20
期刊: Neuron
影响因子: 16.2
作者:
Silbereis JC;Pochareddy S;Zhu Y;Li M;Sestan N
通讯作者: Sestan N
DOI: 10.1093/nar/gku943
发表时间: 2015-01
影响因子: 14.9
作者:
Ran X;Li J;Shao Q;Chen H;Lin Z;Sun ZS;Wu J
通讯作者: Wu J
DOI: 10.1093/nar/gku988
发表时间: 2015-01
影响因子: 14.9
作者:
Quek XC;Thomson DW;Maag JL;Bartonicek N;Signal B;Clark MB;Gloss BS;Dinger ME
通讯作者: Dinger ME