Topographical relationships between arcuate fasciculus connectivity and cortical thickness.
Topographical relationships between arcuate fasciculus connectivity and cortical thickness.
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DOI：
10.1002/hbm.21147
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发表时间：
2011-11
影响因子：
4.8
通讯作者：
Narr, Katherine L.
中科院分区：
文献类型：
--
作者：
Phillips, Owen R.;Clark, Kristi A.;Woods, Roger P.;Subotnik, Kenneth L.;Asarnow, Robert F.;Nuechterlein, Keith H.;Toga, Arthur W.;Narr, Katherine L.
关键词：
弓状神经束（AF）连接在语言处理中重要的皮层区域，但纤维的连贯性和组织如何与灰质宏观结构相关仍然没有表征。我们使用来自36名健康成人（24名男性/12名女性;平均年龄：30.5±9.8岁）的高分辨率结构和30个方向的扩散成像数据来建立AF微结构与语言网络中皮质灰质区域变化之间的关系。皮质模式匹配算法用于测量高空间密度下的灰质厚度，并使用经验证的扩散纤维束成像方法重建每个受试者左右半球的AF。此外，还评估了影像学测量与语言流畅性神经心理学评分之间的关系。结果显示，积极的和高度的地形之间的弓状分数各向异性和皮质厚度在前，后语言区域和周围的皮质，更显着的左半球。这些区域皮质厚度/分数各向异性关系主要归因于径向扩散率的变化。大脑皮层厚度和语言流畅性之间的关联在大脑外侧裂周围的语言相关区域进行了观察。语言评分与左半球AF轴向扩散率相关，但与AF各向异性分数或径向扩散率无关。因此，这些研究结果表明，白色物质的微结构和区域的皮质厚度增加的特定组件有利于语言处理的各个方面。此外，白色物质和灰质完整性的独立措施之间的地形关系表明，丰富的发展或环境的相互作用影响大脑的结构和功能，这种协会的存在和强度可能阐明影响语言系统的病理生理过程。
The arcuate fasciculus (AF) connects cortical regions important in language processing, but how fiber coherence and organization relates to gray matter macrostructure remains uncharacterized. We used high-resolution structural and 30-direction diffusion imaging data from 36 healthy adults (24 male/12 female; mean age: 30.5±9.8 years) to establish the relationships between AF microstructure and regional variations in cortical gray matter within language networks. Cortical pattern matching algorithms were used to measure gray matter thickness at high spatial density, and a validated diffusion tractography method was used to reconstruct the AF in the left and right hemisphere of each subject. Relationships between imaging measures and neuropsychological scores of verbal fluency were additionally assessed. Results revealed positive and highly topographical associations between arcuate fractional anisotropy and cortical thickness within anterior and posterior language regions and surrounding cortices, more prominently in the left hemisphere. These regional cortical thickness/fractional anisotropy relationships were primarily attributable to variations in radial diffusivity. Associations between cortical thickness and verbal fluency were observed in perisylvian language-related regions. Language scores associated with left hemisphere AF axial diffusivity, but not with AF fractional anisotropy or radial diffusivity. These findings thus suggest that particular components of white matter microstructure and regional increases in cortical thickness benefit aspects of language processing. Further, the topographical relationships between independent measures of white matter and gray matter integrity suggest that rich developmental or environmental interactions influence brain structure and function where the presence and strength of such associations may elucidate pathophysiological processes influencing language systems.
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影响因子：
56.9
作者：
GESCHWIN.N
通讯作者：
GESCHWIN.N
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