Small PLGA nanocapsules Co-encapsulating copper sulfide nanodots and fluorocarbon compound for photoacoustic imaging-guided HIFU synergistic therapy.
Small PLGA nanocapsules Co-encapsulating copper sulfide nanodots and fluorocarbon compound for photoacoustic imaging-guided HIFU synergistic therapy.
复制标题
小PLGA纳米胶囊共封装硫化铜纳米点和碳氟化合物用于光声成像引导的HIFU协同治疗
DOI：
10.1039/c7ra12074e
复制
发表时间：
2018-01-24
期刊：
影响因子：
3.9
通讯作者：
Wu, Rong
中科院分区：
文献类型：
--
作者：
Yao, Minghua;Ma, Ming;Xu, Huixiong;Pan, Xiaoxia;Xu, Guang;Wu, Rong
High intensity focused ultrasound (HIFU), as a promising and minimally invasive therapeutic modality against various solid tumors, has received considerable attention in the biomedical field. However, both the accuracy and efficacy of this technique are currently unsatisfactory. Herein, a nanometer-sized organic/inorganic hybrid enhancement agent for photoacoustic imaging (PAI)-guided HIFU therapy was designed and fabricated by concurrently encapsulating both Cu2−xS nanodots (NDs) and perfluorooctyl bromide (PFOB) into a poly(lactic-co-glycolic acid) PLGA nanocapsule (denoted CPPNs). These nanocapsules assumed a unique core/satellite/shell sandwich structure, and combined the merits of small and uniform particle size (about 120 nm), favorable biosafety, and multifunctional theranostic ability into one system. The high performance of Cu2−xS NDs in the absorption and conversion of near infrared laser confers high PAI contrast capability to the CPPNs, by which the location of the CPPNs within a tumor can be monitored successfully under PAI. Furthermore, our in vitro and in vivo results confirmed that the encapsulated PFOB in CPPNs increased the cavitation effect and thus enhanced the ablation efficacy under HIFU exposure. CPPNs show great potential as an efficient and powerful theranostic agent for future PAI-guided HIFU synergistic therapy.
登录
查看更多内容
液固相反转 PLGA 植入物治疗 HIFU 消融后残留肿瘤组织
影响因子：
3.7
作者：
Li J;Krupka T;Yao J;Wang R;Jiang L;Zhou Y;Zuo G;Wang Z;Dai L;Ren J;Zheng Y;Wang D
通讯作者：
Wang D
影响因子：
15
作者：
Moon, Geon Dae;Choi, Sung-Wook;Cai, Xin;Li, Weiyang;Cho, Eun Chul;Jeong, Unyong;Wang, Lihong V.;Xia, Younan
通讯作者：
Xia, Younan
影响因子：
19.7
作者：
Lang, Brian Hung-Hin;Woo, Yu-Cho;Wong, Carlos K. H.
通讯作者：
Wong, Carlos K. H.
影响因子：
12.4
作者：
Menon JU;Jadeja P;Tambe P;Vu K;Yuan B;Nguyen KT
通讯作者：
Nguyen KT
具有超薄二氧化硅涂层的药物-全氟化碳纳米乳剂，用于高强度聚焦超声化疗和消融的协同作用
影响因子：
29.4
作者：
Ma, Ming;Xu, Huixiong;Shi, Jianlin
通讯作者：
Shi, Jianlin