Multimodal imaging of sustained drug release from 3-D poly(propylene fumarate) (PPF) scaffolds.
Multimodal imaging of sustained drug release from 3-D poly(propylene fumarate) (PPF) scaffolds.
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DOI：
10.1016/j.jconrel.2011.06.035
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发表时间：
2011-12-10
期刊：
影响因子：
--
通讯作者：
Gilad AA
中科院分区：
文献类型：
--
作者：
Choi J;Kim K;Kim T;Liu G;Bar-Shir A;Hyeon T;McMahon MT;Bulte JW;Fisher JP;Gilad AA
研究了聚富马酸丙烯酯 (PPF) 支架作为药物载体的潜力，并使用磁共振成像 (MRI) 和光学成像量化药物释放动力学。三种不同的 MR 造影剂用于涂覆 PPF 支架。最初，携带抗癌药物阿霉素的氧化铁（IONP）或氧化锰纳米颗粒（MONP）被吸收或与支架混合，并通过MRI和光学成像测量它们在生理条件下释放到溶液中的情况。观察到药物分子缓慢（数小时至数天）功能性释放到周围溶液中。为了检查蛋白质和多肽的释放特性，将硫酸鱼精蛋白（一种化学交换饱和转移 (CEST) MR 造影剂）附着在支架上。硫酸鱼精蛋白在前 24 小时内表现出稳定的释放速率。由于其生物相容性、多功能载药能力和恒定的释放速率，多孔PPF支架在各种生物医学应用中具有潜力，包括MR引导的药物分配材料的植入、药物运载工具的开发以及肿瘤治疗的药物输送。
The potential of poly(propylene fumarate) (PPF) scaffolds as drug carriers was investigated and the kinetics of the drug release quantified using magnetic resonance imaging (MRI) and optical imaging. Three different MR contrast agents were used for coating PPF scaffolds. Initially, iron oxide (IONP) or manganese oxide nanoparticles (MONP) carrying the anti-cancer drug doxorubicin were absorbed or mixed with the scaffold and their release into solution at physiological conditions was measured with MRI and optical imaging. A slow (hours to days) and functional release of the drug molecules into the surrounding solution was observed. In order to examine the release properties of proteins and polypeptides, protamine sulfate, a chemical exchange saturation transfer (CEST) MR contrast agent, was attached to the scaffold. Protamine sulfate showed a steady release rate for the first 24h. Due to its biocompatibility, versatile drug-loading capability and constant release rate, the porous PPF scaffold has potential in various biomedical applications, including MR-guided implantation of drug-dispensing materials, development of drug carrying vehicles, and drug delivery for tumor treatment.
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影响因子：
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作者：
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影响因子：
3.8
作者：
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