The c.1460C>T polymorphism of MAO-A is associated with the risk of depression in postmenopausal women.
The c.1460C>T polymorphism of MAO-A is associated with the risk of depression in postmenopausal women.
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DOI：
10.1100/2012/194845
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发表时间：
2012
影响因子：
--
通讯作者：
Jagodziński PP
中科院分区：
文献类型：
--
作者：
Słopień R;Słopień A;Różycka A;Warenik-Szymankiewicz A;Lianeri M;Jagodziński PP
objective.本研究的目的是评估绝经后妇女中胆碱能系统基因多态性与抑郁症风险之间的可能关系。方法.我们研究了332名因更年期症状而入住我科的妇女。研究组包括113名根据汉密尔顿抑郁量表诊断为抑郁症的妇女;对照组包括219名无抑郁症的妇女。血清17 β-雌二醇浓度采用放射免疫测定法进行评价，而肾上腺素能系统基因多态性：5-羟色胺受体2A（HTR2A）、1B（HTR1B）和2C（HTR2C）;色氨酸羟化酶1（TPH 1）和2（TPH 2）以及单胺氧化酶A（MAO-A）采用聚合酶链反应-限制性酶切法进行评价。结果研究发现，MAO-A c.1460C> T（SNP 1137070）的1460T等位基因在女性抑郁症患者中的频率显著高于对照组（P = 0.011），且c.1460CT + TT基因型与抑郁症的发病风险相关（P = 0.0198）。1460TT基因型患者的17 β-雌二醇浓度显著高于1460CT基因型（P = 0.0065）和1460CC基因型（P = 0.0018）患者。结论.我们的结论是绝经后妇女抑郁症与MAO-A的遗传贡献密切相关。
Objective. The aim of the study was an evaluation of possible relationships between polymorphisms of serotoninergic system genes and the risk of depression in postmenopausal women. Methods. We studied 332 women admitted to our department because of climacteric symptoms. The study group included 113 women with a diagnosis of depressive disorder according to the Hamilton rating scale for depression; the controls consisted of 219 women without depression. Serum 17β-estradiol concentrations were evaluated using radioimmunoassay, while polymorphisms in serotoninergic system genes: serotonin receptors 2A (HTR2A), 1B (HTR1B), and 2C (HTR2C); tryptophan hydroxylase 1 (TPH1) and 2 (TPH2), and monoamine oxidase A (MAO-A) were evaluated using polymerase chain reaction-restriction. Results. We found that the 1460T allele of MAO-A c.1460C>T (SNP 1137070) appeared with a significantly higher frequency in depressed female patients than in the control group (P = 0.011) and the combined c.1460CT + TT genotypes were associated with a higher risk of depression (P = 0.0198). Patients with the 1460TT genotype had a significantly higher 17β-estradiol concentration than patients with the 1460CT genotype (P = 0.0065) and 1460CC genotype (P = 0.0018). Conclusions. We concluded that depression in postmenopausal women is closely related to the genetic contribution of MAO-A.
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DOI：
10.1002/ajmg.b.30421
发表时间：
2007-06-05
影响因子：
2.8
作者：
Li, Jun;Kang, Chuanyuan;Faraone, Stephen V.
通讯作者：
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影响因子：
11.3
作者：
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作者：
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影响因子：
5
作者：
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通讯作者：
MAGGI, A
影响因子：
0.9
作者：
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通讯作者：
Kennedy, James L.