Prevalence estimates of Helicobacter species infection in pancreatic and biliary tract cancers.
Prevalence estimates of Helicobacter species infection in pancreatic and biliary tract cancers.
复制标题
胰腺和胆道癌中的螺旋细菌感染的患病率估计值。
作者：
幽门螺杆菌感染是胃癌的一个公认的风险因素，并与其他胃肠道疾病，包括胰腺癌和胆道癌有关;然而，肠肝非H.幽门螺杆菌与这些疾病的病理生理学的关系仍不清楚。我们估计了两种肠肝非H的患病率。幽门螺杆菌（肝螺杆菌和胆汁螺杆菌）在一项基于医院的病例对照研究的框架内，涉及121例胆道癌，胰腺癌或其他胃肠道疾病患者。从接受内窥镜逆行胰胆管造影术的患者中收集胆汁和血液样本。H. bilis，H.肝螺杆菌（Helicobacter spp.）使用细菌培养、基于PCR的检测和血清学试验进行检查。幽门螺杆菌的培养胆汁刷样本中提取的DNA没有成功。从各种胃肠道癌症（包括胰腺癌和胆道癌）患者中采集的胆汁样本中，约13.0%（15/115）的一种肝肠非H检测呈阳性。通过PCR确定的幽门螺杆菌的种类。具体来说，H。bilis和H. 11例胆汁中检出肝细胞DNA，4例胆汁中检出肝细胞DNA。大约20%-40%的患者血清非H检测呈阳性。幽门螺杆菌IgG抗体。H. bilis和H.无H. pylori感染在胰腺癌组中似乎高于对照组。我们的研究结果表明螺杆菌的作用，尤其是H。bilis和H.在胰腺癌和胆道癌的病因学中，
Helicobacter pylori infection is a well‐established risk factor for gastric cancer and has been linked to other gastrointestinal diseases, including pancreatic and biliary tract cancers; however, the relevance of enterohepatic non‐H. pylori helicobacters to the pathophysiology of these diseases remains unclear. We estimated the prevalence of two enterohepatic non‐H. pylori helicobacters (Helicobacter hepaticus and Helicobacter bilis) in the framework of a hospital‐based case‐control study involving 121 patients with biliary tract cancer, pancreatic cancer, or other gastrointestinal diseases. Bile and blood samples were collected from the patients undergoing endoscopic retrograde cholangiopancreatography. The presence of H. bilis, H. hepaticus, and other Helicobacter spp. was examined using bacterial culture, PCR‐based detection, and serological tests. Culture of Helicobacter spp. from biliary brush samples was unsuccessful. Approximately 13.0% (15/115) of the bile samples collected from patients with a variety of gastrointestinal cancers, including pancreatic and biliary tract cancers, tested positive for one of the enterohepatic non‐H. pylori helicobacter species as determined by PCR. Specifically, H. bilis and H. hepaticus DNA were detected in 11 and 4 bile samples, respectively. Approximately 20%–40% of the patients tested positive for serum non‐H. pylori helicobacter IgG antibodies. The seroprevalence of H. bilis and H. hepaticus in the patients without evidence of H. pylori infection appeared to be higher in the pancreatic cancer group than in the control group. Our findings suggest a role for Helicobacter spp., especially H. bilis and H. hepaticus, in the etiology of pancreatic and biliary tract cancers.
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影响因子：
8.8
作者：
de Martel, C.;Plummer, M.;Parsonnet, J.;van Doorn, L-J;Franceschi, S.
通讯作者：
Franceschi, S.
影响因子：
4.7
作者：
Fukuda, K;Kuroki, T;Kanematsu, T
通讯作者：
Kanematsu, T
影响因子：
4.3
作者：
Nilsson, Hans-Olof;Stenram, Unne;Wadstrom, Torkel
通讯作者：
Wadstrom, Torkel
影响因子：
4.4
作者：
Segura-Lopez, Fany K.;Aviles-Jimenez, Francisco;Torres, Javier
通讯作者：
Torres, Javier
DOI：
10.1073/pnas.1332093100
发表时间：
2003-06-24
影响因子：
11.1
作者：
Suerbaum, S;Josenhans, C;Fox, JG
通讯作者：
Fox, JG