Predicting bone mineral acquisition during puberty: data from a 3-year follow-up study in Hamamatsu, Japan
Predicting bone mineral acquisition during puberty: data from a 3-year follow-up study in Hamamatsu, Japan
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预测青春期骨矿物质的获取：日本滨松一项为期 3 年的跟踪研究的数据
DOI：
10.1007/s00774-016-0740-4
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发表时间：
2016
影响因子：
3.3
通讯作者：
Iki M
中科院分区：
文献类型：
--
作者：
Kouda K;Ohara K;Nakamura H;Fujita Y;Iki M
虽然大多数成人骨量是在青春期之前获得的，但只有少数研究评估了儿童的骨转换标志物。因此，骨标志物评估和预测儿童骨矿物质积累的效用尚不清楚。本研究评估了11岁时血清骨标志物与随后骨增量变化之间的相关性。基线和3年随访时的骨矿物质和骨标志物信息来自2010年在日本滨松注册为五年级学生的121名儿童。采用双能X线骨密度仪测量全身骨矿含量（WBBMC）和全身骨矿密度（WBBMD）。校正潜在混杂因素后，男孩基线时完整骨钙素与随访时WBBMC之间（β = 0.24）、抗酒石酸酸性磷酸酶同工酶5b（TRAP5b）与WBBMC之间（β = 0.34）以及TRAP5b与WBBMD之间（β = 0.34）存在显著（P< 0.05）正相关。在女孩中，WBBMC和WBBMD的3年增益的校正平均值从1型胶原交联C末端肽的最低四分位数到最高四分位数显著增加。在男孩中，WBBMC和WBBMD的3年增益的校正平均值从TRAP5b的最低四分位数到最高四分位数显著增加。骨转换标志物浓度高的儿童往往表现出骨矿物质的大量积累。这些结果表明，11岁时循环生物标志物的血清水平可预测随后的骨矿物质积累。
Although most adult bone mass is acquired before adolescence, only a few studies have assessed bone turnover markers in children. Thus, the utility of bone markers to evaluate and predict bone mineral accrual in children is unclear. The present study assessed the association between serum bone markers at 11 years of age and subsequent changes in bone gain. Information on bone minerals and bone markers at baseline and at the 3-year follow-up were obtained from 121 children who registered as fifth-grade students in 2010, in Hamamatsu, Japan. Whole-body bone mineral content (WBBMC) and whole-body bone mineral density (WBBMD) were measured using dual-energy X-ray absorptiometry. Boys showed significant (P< 0.05) positive relationships between intact osteocalcin at baseline and WBBMC at follow-up (β = 0.24), between tartrate-resistant acid phosphatase isoenzyme 5b (TRAP5b) and WBBMC (β = 0.34), and between TRAP5b and WBBMD (β = 0.34), after adjusting for potential confounding factors. In girls, adjusted means of 3-year gain in both WBBMC and WBBMD significantly increased from the lowest to highest quartiles of type 1 collagen cross-linked C-terminal telopeptide. In boys, adjusted means of 3-year gain in both WBBMC and WBBMD significantly increased from the lowest to highest quartiles of TRAP5b. Children with a high concentration of bone turnover markers tended to exhibit substantial accrual of bone minerals. These results suggest that serum levels of circulating biomarkers at age 11 predict subsequent bone mineral accrual.
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1634 名健康儿童的血清骨钙素。
影响因子：
9.3
作者：
M. Cioffi;A. Molinari;P. Gazzerro;B. D. Finizio;M. Fratta;Angela Deufemia;G. Puca
通讯作者：
G. Puca
青春期女孩骨质增加的纵向研究：人体测量和生化相关性
影响因子：
6.2
作者：
J. Cadogan;A. Blumsohn;M. Barker;R. Eastell
通讯作者：
R. Eastell
影响因子：
3.3
作者：
Fujita, Yuki;Iki, Masayuki;Yoneshima, Hideo
通讯作者：
Yoneshima, Hideo
瘦体重和脂肪体重、骨生物标志物和性腺类固醇与青春期前和青春期中期骨量的关联
影响因子：
3.2
作者：
V. Csákváry;É. Erhardt;P. Vargha;G. Oroszlán;Tamas Bodecs;Dora Torok;E. Toldy;G. Kovacs
通讯作者：
G. Kovacs
影响因子：
4
作者：
Sabatier, JP;GuaydierSouquieres, G;Denis, AY
通讯作者：
Denis, AY